目录
缩略词中英文对照表 (Ⅰ)
中文摘要 (Ⅱ)
ABSTRACT (Ⅳ)
第一章引言 (1)
1.1中药药渣的研究现状 (1)
1.2 亚精胺类物质研究现状 (3)
1.2.1 亚精胺类物质分类 (3)
1.2.2 亚精胺类物质药理活性 (3)政治方面
1.3 抑郁症研究现状 (4)
1.3.1抑郁症动物模型 (4)
1.3.2抑郁症发病作用机制研究进展 (5)
硬件监控1.3.3抗抑郁药物使用现状 (6)
1.4 立题背景和意义 (7)
1.5研究思路与内容 (7)
第二章亚精胺有效部位提取物抗抑郁作用研究 (9)
2.1实验材料 (9)
2.1.1实验动物 (9)
2.1.2药品试剂 (9)
2.1.3仪器 (9)
2.2实验方法 (10)
2.2.1 亚精胺有效部位提取物的制备 (10)
2.2.2 动物分组与给药 (10)
2.2.3 CUMS模型的建立 (10)
2.2.4糖水偏爱测试 (11)
2.2.5旷场测试 (11)
2.2.6强迫游泳测试 (11)
2.2.7 数据处理 (11)
2.3实验结果 (11)
2.3.1亚精胺有效部位提取物对大鼠体重的影响 (11)
2.3.2亚精胺有效部位提取物对糖水偏爱率的影响 (12)
2.3.3亚精胺有效部位提取物对大鼠旷场实验各指标的影响 (13)
2.3.4亚精胺有效部位提取物对大鼠强迫游泳不动时间的影响 (14)
多大算妇女
2.4小结 (15)
2.5讨论分析 (15)
第三章亚精胺有效部位提取物抗抑郁作用机制研究 (17)
帮忙帮3.1亚精胺有效部位提取物对CUMS模型大鼠单胺类神经递质的影响 (17)
3.1.1 实验材料 (17)
3.1.2 实验方法 (18)
3.1.2.1 样本的收集与制备 (18)
3.1.2.2 对照品溶液和内标溶液的配制 (18)
3.1.2.3 色谱质谱条件 (19)
3.1.2.4 数据处理 (19)
3.1.3 实验结果 (19)
3.1.3.1 CSE对CUMS模型大鼠5-HT代谢途径的影响 (19)
3.1.3.2 CSE对CUMS模型大鼠NE代谢途径的影响 (20)
3.1.4 讨论与分析 (21)
3.2 亚精胺有效部位提取物对CUMS模型大鼠HPA轴激素的影响 (22)
3.2.1 实验材料 (22)
3.2.2 实验方法 (23)
3.2.3 实验结果 (23)
香奈儿介绍3.2.4 讨论分析 (24)
第四章亚精胺有效部位提取物对CUMS模型大鼠血清的影响 (25)
4.1实验材料 (25)
4.1.1 仪器 (25)
4.1.2 试剂 (25)
4.2 实验方法 (25)
4.3 实验结果 (25)
4.3.1 1H-NMR图谱处理 (25)
4.3.2代谢通路分析 (28)
鲢鱼怎么钓4.4 讨论 (29)
第五章总结与展望 (31)
5.1研究总结 (31)
5.2展望和不足 (31)
参考文献 (33)
附录1：亚精胺有效部位提取物液相图谱 (40)
攻读学位期间取得的研究成果 (41)
致谢 (42)
个人情况及联系方式 (43)
承诺书 (44)
学位论文使用授权说明 (45)
Contents
English and chine acronyms (Ⅰ)
Chine abstract (Ⅱ)
ABSTRACT (Ⅳ)
Cheapter 1 Introduction (1)
1.1 Rearch status of Chine medicine residues (1)
1.2 Rearch status of spermidine (3)
1.2.1 Classification of spermidine (3)
1.2.2 Pharmacological activity of spermidine (3)
1.3 Rearch status of depression (4)
1.3.1 Animal model of depression (4)
1.3.2 Mechanisms of depression (5)
1.3.3 Status of antidepressant (6)
1.4 Background and significance (7)
1.5 Rearch ideas and contents (7)
Cheapter 2 Study on antidepressant effects of CSE by CUMS rats (9)
2.1 Experimental materials (9)
2.1.1 Experimental animals (9)
2.1.2 Drugs and reagents (9)
2.1.3 Instruments (9)
番茄炒蛋作文2.2 Experimental methods (10)
2.2.1 Preparation of CSE (10)
2.2.2 Animals grouping and administration (10)
2.2.3 The establishment of CUMS model (10)
2.2.4 Sucro preference test (11)
2.2.5 Open field test (11)
2.2.6 Force swimming test (11)
2.2.7 Statistical analysis (11)
2.3 Experimental results (11)
2.3.1 The effect of body weight on CUMS rats after CSE treat (11)
2.3.2 The effect of sucro preference on CUMS rats after CSE treat (12)
2.3.3 The effect of open field test on CUMS rats after CSE treat (13)
2.3.4 The effect of immobility time in the FST on CUMS rats after CSE treat (14)
2.4 Conclusion (15)
2.5 Discussion and analysis (15)
Cheapter 3 Study on the antidepressant mechanisms of CSE (17)
3.1 The effect of CSE on monoamine neurotransmitter on CUMS rats (17)
3.1.1 Experimental materials (17)
3.1.2 Experimental methods (18)
3.1.2.1 Preparation of samples (18)
3.1.2.2 Preparation of reference solution and standard solution (18)
3.1.2.3 GS/MS conditions (19)
3.1.2.4 Data analysis (19)
3.1.3 Experimental results (19)
3.1.3.1 Effect of CSE on 5-HT metabonomic in CUMS rats (19)
3.1.3.2 Effect of CSE on NE metabonomic in CUMS rats (20)
3.1.4 Discussion and analysis (21)
3.2 The effect of CSE on HPA-axis in CUMS rats (22)
3.2.1 Experimental materials (22)
3.2.2 Experimental methods (23)
3.2.3 Experimental results (23)
3.2.4 Discussion and analysis (24)
Cheapter 4 Effect of CSE on rum of CUMS rats (25)
4.1 Experimental materials (25)
4.1.1 Instruments (25)
4.1.2 Reagents (25)
4.2 Experimental methods (25)
4.3 Experimental results (25)汉朝文书
4.3.1 1H-NMR spectrum processing (25)
