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电脑内存是什么中文摘要 (1)
英文摘要 (3)
英文缩写 (5)
工作态度和责任心总结研究论文沙库巴曲缬沙坦对急性心肌梗死急诊PCI患者心室重构及心功能的影响
被油烫伤疤痕怎么去除前言 (6)
材料与方法 (7)
结果 (12)
讨论 (18)
结论 (20)
参考文献 (21)
诸葛亮相关的成语
综述沙库巴曲缬沙坦在急性心梗心衰患者中的应用 (23)环境保护法全文
致谢 (31)
个人简历 (32)
沙库巴曲缬沙坦对急性心肌梗死急诊PCI患者
心室重构及心功能的影响
摘要
目的：探讨口服沙库巴曲缬沙坦对急性心肌梗死急诊PCI患者心室重构及心功能的影响。
方法：
本研究是一项前瞻性随机对照研究，收集76名确诊急性心肌梗死且行急诊PCI术的患者，随机分成对照组及试验组，每组38例。在抗凝、抗血小板、降脂稳定斑块、控制心室率、抑酸保护胃黏膜等常规治疗的基础上，分别加用依那普利和沙库巴曲缬沙坦。对比两组基线资料、心梗部位以及手术资料；监测住院期间的心梗标志物（cTnI）、NT-proBNP，肾功能指标（肌酐）；记录手术后即刻行的心脏
超声检查所得的左心室射血分数（LVEF）左心室舒张末期前后径（LVEDD）、左室质量指数（LVMI）等指标。并在出院后1个月，3个月，6个月随访时行上述生化及心脏超声检查，并进行KCCQ量化评分，6分钟步行实验（6MWT）。同时对住院期间及随访6个月内的药物不良反应及心脏不良事件进行记录。
结果：两组患者基线资料均无统计学差异（P>0.05）。试验组与对照组梗死部位及介入治疗前后的TIMI血流对比无统计学差异（P>0.05）。在血清学检查中，两组患者入组时的cTnI无统计学差异（P>0.05）。术后1周时，试验组的cTnI低于对照组（P<0.05）。术后2周时，两组患者治疗前的cTnI无统计学差异（P>0.05）。两组患者入组时的NT-proBNP 无统计学差异（P>0.05）。1月时，试验组的NT-proBNP水平低于对照组（P<0.05）。3月时，试验组的NT-proBNP水平低于对照组(P<0.05)。6月时，试验组的NT-proBNP水平低于对照组（P<0.05）。入组时、1月、3月、6月时的CREA检测中，试验组的CREA水平与对照组比较无统计学差异（P>0.05）。在心脏超声检查中，两组患者手术后即刻的LVEF、LVEDD、LVMI水平比较无统计学意义（P＞0.05）。在1月、3月、6月时，试验组LVEF、LVEDD、LVMI结果均优于对照组（P＜0.05）。
在随访调查中，试验组和对照组的KCCQ量表评分及6分钟步行实验（6MWT）结果在1月时比较无统计学意义（P＞0.05），在3月及6月时，试验组KCCQ量表评分及6分钟步行实验（6MWT）的结果优于对照组（P＜0.05）。在两组患者的心脏不良事件及药物不良反应发生率未见明显统计学差异（P＞
空客和波音的区别0.05）。
结论：
对比依那普利，沙库巴曲缬沙坦能够显著改善急性心肌梗死急诊PCI 术患者的心功能，抑制心室重塑，对心力衰竭的临床疗效更佳，且心脏不良事件和药物不良反应的发生率低。
关键词：沙库巴曲缬沙坦，心力衰竭，急性心肌梗死，心室重构藿香正气液说明书
Effects of Sacubitril/Valsartan on ventricular remodeling and cardiac function in patients undergoing emergency PCI after
acute myocardial infarction
玉米烙的家常做法ABSTRACT
Objective:Investigates the improvement of ventricular remodeling and cardiac function in patients with acute myocardial infarction(AMI)after emergency PCI with oral Sacubitril/Valsartan.
Methods:
This is a prospective,randomized,ca-control rearch of76patients undergoing emergency PCI after acute myocardial infarction.They were randomly divided into experimental group(38cas)and control group(38cas).Patients on the basis of routine treatments such as anticoagulation,antiplatelet,lipid-lowering and plaque stabilization, ventricular rate control,acid inhibition and gastric mucosa protection, enalapril and Sacubitril/Valsartan were added respectively.Baline data, myocardial infarction site and surgical data were compared between the two groups；Myocardial infarction markers(cTnI),NT-proBNP and renal function indicators(creatinine)were monitored during hospitalization；The left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter (LVEDD),left ventricular mass index(LVMI)and other indicators were obtained by cardiac ultrasound examination immediately after PCI.Adver drug reactions and adver cardiac events were recorded during hospitalization and within6months of follow-up.
Results:There was no statistical difference in baline data between the two groups(P>0.05).There was no statistically significant difference between the experimental group and the control group in area of infarction and the blood flow of TIMI before and after interventional treatment(P>0.05).In rological examination,there was no statistical difference in cTnI between
the two groups when were enrolled in the test(P>0.05).One week after PCI, the cTnI of the experimental group was significantly lower than that of the control group(P<0.05).Two weeks after PCI,the cTnI was no statistical difference between the two groups(P>0.05).).There was no statistical difference in the NT-proBNP,between the two groups when were enrolled in the test(P>0.05).The NT-proBNP level of the experimental group was significantly lower than that of the control group(P<0.05)at3months and6 months after discharge.The levels of CREA in the experimental group at enrollment and1、3and6months after discharge were not statistically different from tho in the control group(P>0.05).In cardiac ultrasound,there was no significant difference in LVEF,LVEDD and LVMI levels between the experimental group and the control group after PCI immediately (P>0.05).Results of LVEF,LVEDD and LVMI in the experimental group were better than tho in the control group at1、3and6months after discharge(P<0.05).The results of KCCQ score and6-minute walking experiment(6MWT)in the experimental group and the control group were not statistically significant at1month after discharge(P>0.05).The results of KCCQ scale score and6-minute walking experiment in the experimental group were better than tho of the control group(P<0.05)at3and6months after discharge.There was no significant statistical difference in the incidence of cardiac adver events and adver reactions between the two groups(P> 0.05).
Conclusion:
Compared with enalapril,Sacubitril/Valsartan can significantly improve the cardiac function,obstruct ventricular remodeling,more curative effect on suppressing heart failure.Besides the incidence of cardiac adver events and adver reactions is lower.
Keywords:Sacubitril/Valsartan,Acute Myocardial Infarction,Heart failure,Ventricular remodeling
