· 6 ·第29卷 第5期 中国现代医学杂志 Vol. 29 No.5 2019年3月 China Journal of Modern Medicine Mar. 2019
收稿日期：2018-08-08
DOI: 10.3969/j.issn.1005-8982.2019.05.002
文章编号： 1005-8982（2019）05-0006-06
右美托咪定在大鼠脑出血延迟低温治疗中的作用
五好党支部标准
梁威，彭晓红
[武汉市第四医院（华中科技大学同济医学院附属普爱医院） 麻醉科，湖北 武汉 430032]
摘要：目的 探讨右美托咪定在大鼠脑出血后延迟低温治疗中的作用。方法 选取健康雄性SD 大鼠95只，
采用立体定向尾状核注射法复制大鼠脑出血模型，将76只复制成功的大鼠作为手术组，随机分为模型组、延迟
低温组、右美托咪定组、右美托咪定联合延迟低温组，每组19只。余下的为假手术组19只给予手术处置但不注
投资理财基础知识
麻烦的意思射药物，手术组分别给予相应的治疗。对大鼠神经功能缺损（NDS）评分、脑组织水分含量、血肿周围脑组织
细胞凋亡指数、血清炎症细胞因子及脑损伤标志物水平进行检测。结果 治疗后，与模型组比较，各组大鼠NDS
评分及脑组织水分含量较低，且延迟低温组和右美托咪定组均高于右美托咪定联合延迟低温组（P <0.05）
；各组大鼠血肿周围脑组织细胞凋亡指数较低，且延迟低温组和右美托咪定组均大于右美托咪定联合延迟低温组（P <
腌菜扣肉0.05）；各组大鼠血清肿瘤坏死因子α、白细胞介素8水平较低，且延迟低温组和右美托咪定组均高于右美托
咪定联合延迟低温组（P <0.05）与中秋节有关的诗句
；
各组大鼠血清神经元烯醇化酶、S100β蛋白水平较低，且延迟低温组和右美托咪定组均高于右美托咪定联合延迟低温组（P <0.05）
。结论 右美托咪定能够提高延迟低温治疗对大鼠脑出血的疗效，有效改善神经功能缺损，减轻脑组织水肿，抑制脑细胞凋亡，减轻相关炎症反应和脑损伤程度。
关键词： 脑出血；模型，动物；延迟低温治疗；右美托咪定/麻醉药；神经功能缺损
中图分类号： R743.3 文献标识码： A
c罗肌肉Therapeutic effect of Dexmedetomidine on delayed hypothermia treatment of cerebral hemorrhage in rats
Wei Liang, Xiao-Hong Peng
[Department of Anesthesiology, Wuhan Fourth Hospital (Puai Hospital Affiliated To Tongji Medical
College of HUST), Wuhan, Hubei 430032, China]
Abstract: Objective To explore the therapeutic effect of Dexmedetomidine on delayed hypothermia treatmentwin10定时关机命令
of cerebral hemorrhage in rats. Methods Rat model of cerebral hemorrhage was established by stereotaxic caudate
nucleus injection. Rats were randomly divided into model group, delayed hypothermia group, Dexmedetomidine
group and Dexmedetomidine combined with delayed hypothermia group (n = 19). Rats in sham group received all
procedure except hemorrhage. The neurological deficit (NDS) score, brain tissue water content, apoptosis rate in
brain tissue, rum levels of inflammatory cytokines including tumor necrosis factor-α (TNF-α) and interleukin -8
国际商务单证员(IL-8) and brain injury markers were detected. Results Rats in model group experienced an incread levels of NDS
score, brain tissue water content, apoptosis rat in brain tissue around hematoma, rum TNF-α as well as IL-8, rum
neuronal enola (NSE) and S100β protein (S100β) (P < 0.05) when compared with tho in sham group (P < 0.05).
Treatment of Dexmedetomidine or delayed hypothermia induced a significant decrea of the mentioned indexes
compared with model group (P < 0.05) while therapeutic effect of Dexmedetomidine plus delayed hypothermia
was synergistic compared to Dexmedetomidine or delayed hypothermia only group (P < 0.05). Conclusions
Dexmedetomidine enhances the therapeutic effect of delayed hypothermia therapy in rats model of cerebral
