De novo anti-HLA antibody after pandemic H1N1 and asonal influenza immunization in kidney
粗心大意的近义词
transplant recipients.
打工不如创业期刊名称： American Journal of Transplantation
作者： I. Katerinis,K. Hadaya,R. Duquesnoy,S. Ferrari-Lacraz,S. Meier,C. van
Delden,P.-Y. Martin,C.-A. Siegrist,J. Villard
作者机构： Service of Nephrology Department of Medicine University Hospitals of Geneva Geneva Switzerland,Department of Pathology University of
Pittsburgh Medical Center Pittsburgh PA,Center of Vaccinology Department of Pediatrics University Hospitals of Geneva Geneva Switzerland,Division of
爱到骨子里
Transplantation University Hospitals of Geneva Switzerland,
年份： 2011年
期号： 第8期岁月神偷歌曲
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关键词： Antibody-mediated rejection;H1N1 immunization;HLA antibodies;kidney transplantation;Luminex assay
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摘要：In solid organ transplanted patients, annual influenza immunization is strongly recommended becau of morbidity and mortality of influenza infections. In 2009, the rapid spread of a novel H1N1 influenza A virus led to the accelerated development of novel pandemic influenza vaccines. In Switzerland, the recipients received one do of asonal influenza and two dos of AS03-adjuvanted H1N1 vaccines. This situation provided a unique opportunity to analyze the influence of novel adjuvanted influenza vaccines on the production of de novo anti-HLA antibodies. We prospectively followed two independent cohorts including 92 and 59 kidney-transplanted patients, asssing their anti-HLA antibodies before, 6 weeks and 6 months after vaccination. Sixteen of 92 (17.3%) and 7 of 59 (11.9%) patients developed anti-HLA antibodies. The antibodies,...
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