专利名称：F3-PEPTIDE TARGETED LIPID-BASED
感谢公司NANOPARTICLES USEFUL FOR THE
TREATMENT OF ANGIOGENESIS-
DEPENDENT DISEASES
发明人：SERENO DE ALMEIDA MOREIRA, JOÃO
农机推广
NUNO,GOMES DA SILVA, Lígia
Catarina,BIMBO, Luís,OLIVEIRA DOS
皮草自己在家怎么清洗SANTOS, Adriana,PEDROSO DE LIMA, María
da Conceição,DE MAGALHÃES SIMÕES,
Sérgio Paulo
申请号：PT2011/000008
威海景区申请日：20110322
公开号：WO2011/119058A3
公开日：
五年级阅读记录卡
20120412
专利内容由知识产权出版社提供猎头局中局
摘要：The prent invention relates to F3 -peptide targeted lipid-bad nanoparticles, adequate to encapsulate and delivery- one or more nucleic acids, comprising; a) one or more nucleic acids; b) on
e or more cationic lipids; c) one or more non- cationic lipids; d) one or more poly (ethylene glycol) - derivatized lipids; and e) one or more coupled targeting ligands which bind to the nucleolin receptor. The nanoparticles according to the invention have a high loading capacity, ability to protect the encapsulated nucleic acid, a size below 250 ran and a charge clo to neutrality, which are adequate features for intravenous administration. The nanoparticles of the prent inventon have the ability to lectively delivery a siRNA to cancer cells and/or endothelial cells from angiogenic
blood vesls leading to an effective silencing of a target gene. The nanoparticles are ud for the treatment of angiogenesis- dependent dias, namely cancer, inflammation, an auto-immune dia or an ocular disorder.
数学小报手抄报申请人：UNIVERSIDADE DE COIMBRA,CENTRO DE NEUROCIÊNCIAS E BIOLOGIA CELULAR,SERENO DE ALMEIDA MOREIRA, JOÃO NUNO,GOMES DA SILVA, Lígia Catarina,BIMBO, Luís,OLIVEIRA DOS SANTOS, Adriana,PEDROSO DE LIMA, María da Conceição,DE MAGALHÃES SIMÕES, Sérgio Paulo
地址：PT,PT,PT,PT,FI,PT,PT,PT茶经
国籍：PT,PT,PT,PT,FI,PT,PT,PT
代理人：PEREIRA DA CRUZ, João
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