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absolute prediction error(s) (APE)绝对预测误差absorption, distribution, metabolism, elimination (ADME)吸收、分布、代谢、消除active transport主动转运
adaptive design自适应性设计
additive error加和性误差
adherence依从性
海洋生物图administration给药
affinity亲和力
agonist激动剂
allometric scaling异速生长
antagonist拮抗剂
area under curve (AUC)曲线下面积assumptions假设
auto-induction自诱导
backward elimination逆向剔除法
ba model基础模型
baline基线
below the limit of quantification (BLQ)低于定量下限
between-subject variability (BSV)个体间变异
bias偏差
biliary clearance胆汁清除率bioavailability生物利用度bioequivalence生物等效性
biomarker生物标志物biopharmaceutics classification system (BCS)生物药剂学分类系统blood血
body mass index (BMI)体质指数
body surface area (BSA)体表面积
bolus推注
bootstrap自举法
bottom-up appraoch自下而上的模式capacity-limited metabolism能力限制型代谢categorical data分类数据
catenary compartment model链式模型
causality因果
chi-square test卡方检验
clearance清除率
Clinical trial simulation临床试验模拟
clinical utility index临床效用指数
Cmax峰浓度
coefficient of variation (CV)变异系数Compartmental analysis房室模型分析competitive inhibition竞争性抑制
compliance依从性
concomitant medication effect联合用药效应
condition number条件数
conditional probability条件概率
conditional weighted residuals (CWRES)条件加权残差confidence interval置信区间
constitutive model本构模型
continuous data连续数据
convergence收敛
correlation相关
correlation coefficient相关系数correlation matrix相关矩阵
count data计数数据covariacne matrix协方差矩阵covariance协方差
covariate evaluation协变量评价covariate model协变量模型creatinine clearance肌酐清除率
甚器尘上cross-over design交叉设计
data analysis plan数据分析计划datat asmbly/construction数据集建立datat specification file数据库规范文件degrees of freedom自由度
dependent variable (DV)因变量determinant行列式deterministic identifiability确定性可识别性deterministic simulation确定性模拟diagonal matrix对角矩阵dichotomous二分类
direct-effect model直接效应模型discrete离散
dia progression疾病进程
dia-modifying effect疾病缓解效应do dependence剂量依赖性冰河世纪树懒
do-normalized concentrations剂量归一化浓度double-blind双盲
drug accumulation药物蓄积
drug-drug interaction药物-药物相互作用duration of infusion输注持续时间efficacy功效
eigenvalues特征值
empirical Bayesian estimates (EBEs)经验贝叶斯估计endogenous内源性enterhepatic circulation肝肠循环
estimate估计值
estimation求参
exogenous外源性exploratory data analysis (EDA)探索性数据分析exponential指数型
external validation外部验证extrapolation外推extravascular administration血管外给药
fasted禁食
fed进食
first in human (FIH) trial首次人体试验
first-order absorption一级吸收
first-order conditional estimation method (FOCE)一阶条件估计法first-order method (FO)一阶评估法
first-pass effect首过效应
Fisher information matrix Fisher信息矩阵fixed effect固定效应
flip-flop翻转
forward lection前向选择
fraction of unbound (fu)游离分数
full agonist完全激动剂gastric emptying胃排空
generic products仿制药
genetic polymorphism遗传多态性genome-wide association study (GWAS)全基因组关联研究genotype基因型
global minimum全局最小值global nsitivity analysis全局敏感性分析glomerular filtration rate (GFR)肾小球滤过率goodness of fit拟合优度gradient梯度
half maximal inhibitory concentration (IC50)半数抑制浓度
half-life半衰期
hepatic clearance肝清除率hierarchical层级homeostasis稳态homoscedasticity方差齐性hysteresis滞后
identity matrix单位矩阵
ill-conditioned matrix病态矩阵immunogenicity免疫原性
鱼糕怎么吃
in silico经由电脑模拟
in situ原位
in vitro体外
in vivo体内independent variable自变量
indirect respon model间接反应模型individual parameter estimates个体参数估计individual prediction (IPRED)个体预测值individual residuals (IRES)个体残差individual weighted residuals (IWR
ES)个体加权残差infusion输注
initial estimate起始参数估计inter-individual variability (IIV)个体间变异internal validation内部验证
inter-occasion variability场合间变异interpolation插值
intestinal absorption肠道吸收
intra-individual variability个体内变异intramuscular administration (i.m.)肌肉注射intravenous administration (i.v.)静脉给药
intrinsic clearance内在清除率inver agonist反向激动剂inver of matrix逆矩阵isobologram等效线图Jacobian matrix雅可比矩阵
lag time滞后时间
large-scale systems model大型系统模型lean body weight瘦体重
level 1 random effect (L1)一级随机效应level 2 random effect (L2)二级随机效应ligand-receptor binding配体-受体结合likelihood ratio test似然比检验
linear models线性模型
linear pharmacokinetics线性药物动力学住址英文
local minimum局部最小值
local nsitivity analysis局部敏感性分析
locally weighted scatterplot smoothing (LOWESS)局部加权散点平滑法logistic regression Logistic回归
logit transform Logit变换
log-normal distribution对数正态分布
log-transformation对数变换
maintenance do维持剂量
marginal probability边际概率
mean均值
mean absolute prediction error percent (MAPE)平均绝对预测误差百分比mean prediction error (MPE)平均预测误差
mean residence time (MRT)平均滞留时间
mean squared error (MSE)均方误差
mechanism-bad inhibition基于机制的抑制
median中位数
Michaelis-Menten constant米氏常数
Michaelis-Menten kinetics米氏动力学
missing dependent variable (MDV)缺失应变量香气扑鼻是成语吗
mixed effect混合效应
mixture models混合模型
model diagnostic plots模型诊断图
model evaluation模型评价
model misspecification模型错配
model specification file (MSF)模型规范文件
model validation模型验证
Model-bad drug development基于模型的药物研发moment矩
Monte Carlo simulation蒙特卡洛模拟multivariate linear regression多元线性回归
negative feedback负反馈
nested嵌套
Non-compartmental analysis非房室模型分析noncompetitive inhibition非竞争性抑制
nonlinear mixed effect models (NONMEM)非线性混合效应模型nonlinear pharmacokinetics非线性药物动力学normal distribution正态分布
normalized prediction distribution errors (NPDE)归一化预测分布误差numerical predictive check (NPC)数值预测性能检查objective function value (OFV)目标函数值
obrvation观测
手工妈妈occupancy占有
occupational model受体占有模型
one-/two-compartment model一/二室模型
ont of effect起效
operational model操作模型
optimal sampling最优采样
Optimal study design优化试验设计
oral口服
ordered data有序数据
outlier离群值
parallel design 平行设计
partial agonist部分激动剂
peak concentration峰浓度
perfusion灌注
permeability渗透性Pharmacodynamics药效动力学Pharmacogenomics药物基因组学Pharmacokinetics 药物动力学Pharmacometrics定量药理学
pha I reaction第一相反应
pha II reaction第二相反应phenotype表型
Physiologically bad pharmacokinetics (PBPK)生理药物动力学piecewi linear models分段线性模型
placebo安慰剂
plasma血浆
Poisson distribution泊松分布
Poisson regression泊松回归
population pharmacokinetics群体药物动力学positive feedback正反馈
post hoc事后
posterior distribution后验分布
posterior predictive check (PPC)后验预测性能检查posterior probability后验概率
potency效价强度
power function幂函数
precision精密度
pre-clinical study临床前研究
prediction (PRED)群体预测值
prediction error (PE)预测误差
prior distribution先验分布
prodrug前药
火车zproof of concept study概念验证研究proportional error比例型误差
Q-Q plot分位图
quality assurance (QA)质量保证
quality control (QC)质量控制
random effect随机效应randomisation 随机化
rate constant速率常数
rate-limiting step限速步骤
reference group对照组
relative bioavailability相对生物利用度relative standard deviation (RSD)相对标准偏差
relative standard error (RSE)相对标准误
renal clearance肾清除率reparameterization重新参数化
repeat do重复剂量
resampling重采样
residual (RES)残差
residual unexplained variability (RUV)残留不明原因的变异·rich sampling密集采样
robust鲁棒性
root mean square error (RMSE)均方根误差
rounding errors舍入误差
saturable可饱和的
