中国有哪些地方Immunoevasion and immunosuppression of the macrophage by Mycobacterium tuberculosis 期刊名称： Immunological Reviews
作者： Hmama, Zakaria, Pe?a-Díaz, Sandra, Joph, Sunil, Av-Gay, Yosf
年份： 2015年
雪菜怎么做好吃期号： 第1期飞行员一个月工资多少>孕检报告
五圣关键词： macrophages;bacterial;protein kinas;phagocytosis
学业奖学金
摘要：Summary By virtue of their position at the crossroads between the innate and adaptive immune respon, macrophages play an esntial role in the control of bacterial infections. Paradoxically, macrophages rve as the natural habitat to Mycobacterium tuberculosis (Mtb). Mtb subverts the macrophage's mechanisms of intracellular killing and antigen prentation, leading ultimately to the development of tuberculosis (TB) dia. Here, we describe mechanisms of Mtb uptake by the macrophage and address key macrophage functions that are targeted by Mtb-specific effector molecul
es enabling this pathogen to circumvent host immune respon. The macrophage functions described in this review include fusion between phagosomes and lysosomes, production of reactive oxygen and nitrogen species, antigen prentation and major
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