跆拳道操Cisplatin and Aminoglycoside Antibiotics: Hearing
一什么窟窿Loss and Its Prevention
婴儿鼻塞流鼻涕
期刊名称： 《Anatomical Record-advances in Integrative Anatomy & Evolutionary Biology》西藏穷游>深圳特产
作者： Schacht, Jochen,Talaska, Andra E.,Rybak, Leonard P.物体间力的作用是
年份： 2012年
期号： 第11期
关键词： aminoglycosides; cisplatin; ototoxicity; oxidative stress; otoprotection
作文材料摘要：This review introduces the pathology of aminoglycoside antibiotic and the cisplatin chemotherapy class of drugs, discuss oxidative stress in the inner ear as a primary trigger for cell damage, and delineates the ensuing cell death pathways. Among potentially ototoxic (damaging the inner ear) therapeutics, the platinum-bad anticancer drugs and the aminoglycoside antibiotics are of 美丽的人
critical clinical importance. Both drugs cau nsorineural hearing loss in patients, a side effect that can be reproduced in experimental animals. Hearing loss is reflected primarily in damage to outer hair cells, beginning in the basal turn of the cochlea. In addition, aminoglycosides might affect the vestibular system while cisplatin ems
to have a much lower likelihood to do so. Finally, bad on an understanding the mechanisms
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