Regulation of platelet aggregation by post-fibrinogen binding events. Insights provided by dithiothreitol-treated platelets.
期刊名称： Thrombosis and Haemostasis
安全反思材料作者： Ellinor I Peerschke
年份： 1995年
中国美食之都期号： 第5期创新的成语
红萝卜汁野荷塘视频摘要：A variety of data suggest that fibrinogen binding is necessary but not sufficient for platelet aggregation: post fibrinogen binding events may play an important role. The prent study compared fibrinogen binding and platelet aggregation in respon to dithiothreitol (DTT) and ADP. DTT induced saturable and specific fibrinogen binding (Kd 0.07 + 0.02 μM, Bmax 15,000 + 3000 molecules/platelet) which supported complete platelet aggregation as determined by single platelet counting. The aggregates were small, however, and more readily dissociated by EDTA than their ADP-treated counter
parts, despite quantitatively similar fibrinogen binding. Unlike fibrinogen bound to ADP-stimulated platelets, fibrinogen bound to DTT-treated platelets remained nsitive to dissociation by EDTA over a 3 h time cour, retained its ability
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