542020年6月第6卷第6期
*临床与实践*
宝宝几个月会吃手尿转铁蛋白在诊断风湿病患者早期肾损害中的应用研究
王丽芳，董鹏，刘伟，宋慧
北京积水潭医院风湿免疫科，北京100035
怕冷的人>成方园摘要目的尿转铁蛋白是反映肾小球滤膜损伤的灵敏指标，该文旨在探讨尿微量蛋白在风湿病患者早期肾损害中的诊断意义"方法对2005年1月一2010年9月北京积水潭医院风湿免疫科门诊和住院的631例风湿病患者尿液中微量蛋白进行检测。结果与非SLE患者相比，SLE患者尿中MA(!<0.01)、TRF(!<0.0001)、IgG(!<0.05)增高例数百分比显著升高，两组比较a1-MG$ NAG差异无统计学意义(！>0.05)。SLE患者尿中MA(!<0.05)、TRF(!<0.0001)水平较非SLE患者显著升高，两组患者尿中a1-MG、IgG、NAG水平比较差异无统计学意义(Q0.05)。与肾损伤SLE患者组相比，伴肾损伤组SLE患者组尿中MA、！1-MG、TRF、IgG水平均升高(！<0.05)。两组患者尿中NAG水平相比差异无统计学意义(Q0.05)。相关性分析显示,SLE患者尿微量蛋相关(！<0.05)。SLE患者尿中MA、TRF、IgG与肾损伤指标——尿蛋白、尿红细胞及管型相关(！< 0.05)o与疾病活动指标的相关性分析显示,SLE患者尿中TRF水平与ESR(#<0.389)呈正相
关(！<0.05)。尿中IgG水平与ESR (#<0.602)呈正相关(！<0.05)，与补体C3(#二-0.317,!<0.05)呈负相关。其余相关性无统计学意义(Q0.05)。结与其他风湿病相比，TRF分量小、，且检测、快速、有效和无创伤性，在SLE患者早期肾损伤的诊断中具有广阔的。怎样开热点
零极限
小狗的小房子读后感名师风采统；转铁蛋白*早期肾损害
中图分类号R593.24+2文献标志码A doil0.11966/j.issn.2095-994X.2020.06.06.18
Application Study of Urinary Transferrin in the Diagnosis of Early Renal Damage in Patients with Rheumatism
WANG Li-fang,DONG Peng,LIU Wei,SONG Hui
Department of Rheumatology and Immunology,Beijing Jishuitan Hospital,Beijing,100035China
自行车类型Abstract Objective Urinary transferrin is a nsitive indicator reflecting glomerular membrane damage.This article aims to explore the diagnostic significance of urinary microproteins in early renal damage in rheumatic patients.Methods The trace protein in urine of631 rheumatic patients in the outpatient and inpatient department of rheumatology and immunology in Beijing Jishuitan Hospital from January2005to September2010was detected.Results Compared with non-SLE patients,the per
centage of cas with incread urine MA(!<0.01),TRF(!<0.0001),IgG(!<0.05)in SLE patients was significantly incread,and there was no statistically significant difference in a1-MG and NAG between the two groups difference(!>0.05).The urine MA(!<0.05)and TRF(!<0.0001)levels in SLE patients were significantly higher than tho in non-SLE patients.There was no significant difference in urine a1-MG,IgG and NAG levels between the two groups(!>0.05).Compared with the SLE patient group without kidney injury,the urine MA,a1-MG,TRF and IgG levels in the SLE patient group with kidney injury group were incread(!<0.05).There was no statistically significant difference in urine NAG levels between the two groups(!>0.05).Correlation analysis showed that there was a positive correlation between urine microproteins in patients with SLE(!<0.05).Urine MA,TRF and IgG in SLE patients were positively correlated with indicators of kidney damage-urine protein,urine red blood cells and cast(!<0.05).Correlation analysis with dia activity indicators showed that
收稿日期：2020—05—06；修回日期：2020—05—27
作者简介：王丽芳(1982—)，女，山西临县人，博士，主治医师，研究方向：自身免疫病。
通讯作者：宋慧(1964-)，女，天津人，硕士，副主任医师，研究方向：自身免疫病，E—mail:****************$
