Ubiquitin e3 liga itch negatively regulates osteoblast differentiation from menchymal
英语语法基础入门
progenitor cells.
东方佳人期刊名称： Stem Cells
作者： Zhang Hengwei,Xing Lianping
伤感歌曲40首听了流泪
沟壑年份： 2013年
期号： 第8期
袋鼠怎么画
关键词： Itch;E3 liga;Menchymal progenitor cells;Osteoblasts;Bone初中读后感
formation在新的一年里
摘要：Itch, a HECT family E3 liga, affects numerous cell functions by regulating ubiquitination and proteasomal degradation of target proteins. However, the role of Itch in osteoblasts has not been investigated. We report that Itch−/− mice have significantly incread bone volume, osteoblast number
象棋段位
s, and bone formation rate. Using bone marrow stromal cells from Itch−/− mice and wild-type (WT) littermates as bone marrow menchymal precursor cells (BM-MPCs), we found that BM-MPCs from Itch−/− mice have compatible numbers of cells expressing menchymal stem cell markers. However, Itch−/− BM-MPCs grew faster in an in vitro culture, formed more CFU-F menchymal colonies, and exhibited incread osteoblast differentiation and decread adipogenesis. Importantly, Itch−/− menchymal colony cells formed significantly
内容由中国教育图书进出口有限公司引进
