第37卷第4期 2018年 8月
北京生物医学工程
Beijing Biomedical Engineering
Vol.37 No.4
August2018
.论著.
基于脑网络信息传递特性的癫痫病灶区定位
左锐1张旭1魏婧1梁莹1李春林1赵翠1仲奕画1成昊1张国君2
摘要目的癫痫是一种反复发作的慢性脑疾病，严重危害患者身心健康。如何精确定位癫痫病灶区是目前医学研究热点之一。本文旨在基于脑网络信息传递特性定位癫痫病灶区，期望为临床确诊病灶区提供创新思路。方法应用频域因果连接分析构建5位颞叶癫痫患者颅内脑电特征频段因果网络，计算网络节点因果流。结果（1)颞叶癫痫患者颅内脑电能量分布优势频带是s、e频段，s、e频段能量显著高于其他频段，
病灶区能量分布高于非病灶区。（2)颞叶癫痫患者病灶区因果流小于〇，非病灶区因果流大于〇。结论（1)颞叶癫痫患者颅内脑电特征频段为s、e，病灶区特征频段能量异常增强。
(2)颞叶癫痫患者因果网络中，被定义为因果汇的脑区为临床确诊病灶区，因果源脑区为非病灶区，病
灶区易受非病灶区影响。
关键词癫痫病灶区定位；颅内脑电信号；脑网络；定向传递函数；因果流
DOI: 10. 3969/j.issn. 1002-3208. 2018.04.001.
中图分类号R318. 04 文献标志码A 文章编号1002-3208(2018)04-033卜06
Epileptogenic focus localization through information transfer
characteristic bad on brain networks
ZUO R u i1，ZHANG X u1，W EI Jing1，LIANG Y ing1，LI C hunlin1，
ZHAO C ui1，ZHONG Y ihua1，CHENG H ao1，ZHANG G uojun2
1 Bei j ing Key Laboratory o f Fundamental Rearch on Biomechanics in Clinical Application，
Capital Medical Uni v ersity，Bei j ing 100069;2 Bei j ing Institute o f Functional Neurosurgery，
Xuanwu Hospital Capital Medical Uni v ersity，Bei j ing100053
Cooresponding author：ZHANG Xu(E-mail：zhangxu@ ccmu. edu. cn)
【Abstract] Objective E pilepsy is a chronic and relapsing brain d i a，and verely threatens physical and m ental health of the patients. How to precily locate the epileptogenic focus has becom e a new hotpoint of m edical rearch. The aim of this paper is to locate the epileptogenic focus through inform ation transfer characteristic bad on brain netw orks，and to provide new insights for epileptogenic focus localization. Methods The experim ental data are intracranial EEG s obtained from 5 patients with tem poral lobe epilepsy.
The causality analysis in frequency dom ain is applied to construct causality network of the characteristic frequency bands of EEG s and com pute causal flow of network nodes. Results (1)The advantage of the energy distribution of EEG in the patients with tem poral lobe epilepsy are delta and theta frequency，the energy of delta
基金项目：首都卫生发展科研专项项目（2016-1-2011)资助 作者单位：1首都医科大学临床生物力学应用基础研究北京 市重点实验室（北京100069)
2首都医科大学宣武医院北京功能神经外科研究 所（北京100053)
通信作者：张旭，教授。E-mail: zhangxu@ccmu.edu. cn and theta frequency are greater com pared to the other bands. The energy in the focus are greater com pared to the corresponding bands in the non-focus. (2)Causal flow value in the focus of tem poral lobe epilepsy is less than 0，w hile in the non-focus is greater than 0. Conclusions (1)The characteristic frequency bands of
