Immunoglobulin E and G antibodies two years after a booster do of an aluminium-adsorbed or a fluid
DT vaccine in relation to atopy.
期刊名称： Pediatric Allergy & Immunology
作者： Anders Mark, Bengt Bj?rkstén, Marta Granstr?m
年份： 2010年
期号： 第2期
关键词： immunoglobulin E ; booster vaccination ; aluminium adjuvant ;
diphtheria-tetanus (DT) vaccine
摘要：Iinnumoglobi. il in E and G levels lo diphtheria and tetanus toxoids were investigated two years after a DT booster wilh either an adsorbed or a nonadsorbed, fluid vaccine, given at 10 years of age. Although IgE levels had declined, detectable IgE to diphtheria and tetanus toxoids were still found in 82
% and 67% of samples, respectively, to be compared to prebooster levels of 3-14% and postbooster levels of 92-94%. The IgG levels had also declined hut remained at equal and high levels in both the adsorbed and the fluid vaccine groups. The prevalence of allergic symptoms was similar in the two vaccination groups. Thus, the study showed an unexpected, long duration of the IgE respons elicited by a booster do of DT vaccine. The booster do also induced a durable, high IgG antibody respon to both the adsorbed and the fluid vaccine.
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