斐凡立善
汗疱疹症状Dynamic expression patterns of leucine-rich repeat containing protein 10 in the heart.
期刊名称： Developmental Dynamics
节后上班通知作者： Ki‐Hyun Kim,Tae‐Gyun Kim,Bruce K. Micales,Gary E. Lyons,Youngsook Lee 年份： 2010年
关键词： leucine‐rich repeat containing protein 10;LRRC10;cardiac‐specific
gene;heart development;subcellular localization;striations in cardiomyocytes暂时存放
碧沽天池摘要：Leucine-rich repeat containing protein 10 (LRRC10) is a heart-specific红棺材
factor who function remains unknown. Examination of the intracellular location of the gene products is a critical step in determining the biological functions of the protein. Our expression analys in mice indicate that LRRC10 is exclusively expresd from the precardiac region in early embryos to the adult heart. LRRC10 expression is markedly elevated upon birth, suggesting its role in the embryonic as well as adult hearts. Of interest, LRRC10 exhibits dynamic intracellular expression patterns in cardiomyocytes. Cardiomyocytes from embryos and newborns show diffu cytoplasmic and nuclear st
aining of LRRC10. In contrast, striking striations
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are obrved in adult cardiomyocytes, which are colocalized with the markers for
the Z-line, sarcoplasmic reticulum (SR),
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