Identification and characterization of novel stable deoxyguanosine and deoxyadenosine adducts of benzo[a]pyrene-7,8-quinone from reactions at植物保护
physiological pH.
瞻仰意思期刊名称： Chemical Rearch in Toxicology女生手脚冰凉
作者： Narayanan Balu,William T Padgett,Guy R Lambert,Adam E Swank,Stephen Nesnow
年份： 2004年
向上的句子期号： 第6期
关键词： Dimethylformamide;Benzopyrenes;Benzo(a)pyrene;DNA
Adducts;Deoxyadenosines;Deoxyguanosine;Chromatography, High Pressure Liquid;Spectrophotometry, Ultraviolet;Magnetic Resonance
写人记事发芽葱Spectroscopy;Spectrometry, Mass, Electrospray Ionization
摘要：Benzo[a]pyrene (B[a]P) is an archetypal member of the family of polycyclic aromatic hydrocarbo
阿拉蕾崔雅涵ns (PAHs) and is a widely distributed environmental pollutant. B[a]P is known to induce cancer in animals, and B[a]P-containing complex mixtures are human carcinogens. B[a]P exerts its genotoxic and carcinogenic effects through metabolic activation forming reactive intermediates that damage DNA. DNA adduction by B[a]P is a complex phenomenon that involves the formation of both stable and unstable (depurinating) adducts. One pathway by which B[a]P can mediate genotoxicity is through the enzymatic formation of B[a]P-7,8-quinone (BPQ) from B[a]P-7,8-diol by members of the aldo-keto-reducta (AKR) family. Once formed, BPQ can act as a reactive Michael acceptor that can alkylate cellular nucleophiles including DNA and peptides. Earlier
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