显示屏亮度调节
宝宝生日蛋糕Characterization of osthenol metabolism invivo and
五仁酥its pharmacokinetics
期刊名称： Xenobiotica; the fate of foreign compounds in biological systems
作者： Piljoung Cho,Su Min Choi,Younah Kim,Doo Hyun Lee,Yeeun Noh,Sujeong五月雪
蛇的特点
Kim,Ju-Hyun Kim,Taeho Lee,Sangkyu Lee
年份： 2020年
关键词： Osthenol;pharmacokinetics;sulfonation;glucuronidation;first-pass
effect;bioavailability
节气表>任士荣
摘要：Osthenol, a prenylated coumarin, is a C8-prenylated derivative of umbelliferone isolated from the root of Angelica koreana and Angelica dahurica , an intermediate and is known as a major metabolite of desmethyl-osthole. The various pharmacological effects of osthenol have been reported. I
n previous studies, we investigated five hydroxylated metabolites by cytochromes P450 (CYP) and glucuronide conjugates of osthenol by uridine diphosphate-glucuronosyltransferas (UGTs). However, osthenol have very few studies have been reported on its pharmacokinetic (PK) profiling, we reported the PK parameters in mou of osthenol through this study. After oral (5 and 20mg/kg)
空中三角测量and intravenous (5mg/kg) administration, the concentration of osthenol in plasma was determined by LC-MS/MS. The quantitative method was validated in terms of linearity,...
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