专利名称：SHIKONIN, ALKANNIN, AND RACEMIC
PARENT NUCLEUS CARBONYL OXIME
DERIVATIVES AND APPLICATIONS THEREOF 发明人：LI, SHAOSHUN,WANG, RUBING,ZHENG,
XIAOGANG,ZHANG, XU
申请号：EP13871854
申请日：20130625
蒜苗儿公开号：EP3002276A4世界第一大桥
牛的象征
公开日：珍珠的作用和功效
20160525
专利内容由知识产权出版社提供
房陵摘要：The prent invention disclos derivatives of shikonin, alkannin and a racemic mixture thereof with hydroxyl methylation and carbonyl oximation on the parent nucleus, and their application. The derivatives of shikonin with hydroxyl methylation and carbonyl oximation on the parent nucleus have structural formula (I) or (II); the derivatives of alkannin with hydroxyl methylation and carbonyl oximation on the parent nucleus have structural formula (III) or (IV); the derivatives of a racemic mixture of shikonin and alkannin with hydroxyl methylation and carbonyl oximation on the parent nucleus have structural formula (V) or (VI); wherein R 1 is alkane, olefin, arene, or substituted arene comprising 1 to 6 carbon atoms; and R 2 is alkane, olefin, arene, or substituted arene comprising 1 to 6 carbon atoms or is H. The oxime derivatives of shikonin, alkannin and a racemic mixture thereof in the prent invention have novel structures; and in-vitro experiments show that said derivatives of the prent invention have good growth inhibitory activity against tumor cells and thus can be ud in tumor treatment.
狗牙雨
申请人：SHANGHAI JIAOTONG UNIVERSITY
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