专利名称：GENETICALLY-ENGINEERED MESENCHYMAL STEM CELLS OVEREXPRESSING AOAH AND百叶卷肉
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USES THEREOF
发明人：CALLAHAN, Michael,MEI, Shirley H.J.,WANG, Yan,FLORIAN, Maria,ROWE, Katelynn,LEE,
Chyan-jang
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申请号：EP19878837.4
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申请日：20191029
公开号：EP3874029A1
祭海公开日：
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20210908
专利内容由知识产权出版社提供
摘要：Genetically-modified menchymal stem cells (MSCs) overexpressing an acyloxyacyl hydrola (AOAH) polypeptide, such as MSCs comprising a recombinant nucleic acid encoding the AOAH polypeptide, are described. The MSCs may further overexpress a cond polypeptide of interest, such as angiopoeitin-1 (ANGPT1). Pharmaceutical compositions comprising the genetically-modified MSCs are also described. The u of such genetically- modified MSCs and/or pharmaceutical compositions comprising same as a medicament, for example for the treatment of systemic inflammatory respon syndrome (SIRS) or psis, is also described.
申请人：Ottawa Hospital Rearch Institute,United Therapeutics Corporation
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地址：501 Smyth Road Ottawa, Ontario K1H 8L6 CA,1040 Spring Street Silver Spring, MD 20910 US
男人好难mtv国籍：CA,US
代理机构：Lavoix
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