专利名称：UDP-N- acetylglucosamine: (to GalNAc from GlcNAc) galacto -β1,3-N-社会习俗
acetylgalactosamine -α-R / N-
acetylglucosamine -β1,3-N-
acetylgalactosamine -α-R β1,6-N -
acetylglucosaminyltransfera, C2 / 4GnT 发明人：クラウセン、ヘンリック,シュヴィエンテク、ティロ
申请号：JP特願2000-586883(P2000-586883)怎么和女生说早安
衢州三头一掌
申请日：19991203
公开号：JP特表2002-531120(P2002-531120A)A生物七下
公开日：掖怎么读
20020924
专利内容由知识产权出版社提供
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摘要：A novel gene defining a novel human UDP-GlcNAc: Gal/Gl cNAcbeta 1-3GalNAc alphabeta1, 6GlcNAc-transfera, termed C2/4GnT, with unique enzymatic properties is disclod. The enzymatic activity of C2/4GnT is shown to be distinct from that of previously identified enzymes of this gene family. The invention disclos isolated DNA molecules and DNA constructs encoding C2/4GnT and derivatives thereof by way of amino acid deletion, substitution or inrtion exhibiting C2/4GnT activity, as well as cloning and expression vectors including such DNA, cells transfected with the vectors, and recombinant methods for providing C2/4GnT. The enzyme C2/4GnT and C2/4G
nT-active derivatives thereof are disclod, in particular soluble derivatives comprising the catalytically active domain of C2/4GnT. Further, the invention disclos methods of obtaining 1,6-N-acetyl glucosaminyl glycosylated saccharides, glycopeptides or
glycoproteins by u of an enzymically active C2/4GnT protein or fusion protein thereof or by using cells stably transfected with a vector including DNA encoding an enzymatically active C2/4GnT protein as an expression system for recombinant production of such glycopeptides or glycoproteins. Also a method for the identification for the identification of DNA quence variations in the C2/4GnT gene by isolating DNA from a patient, amplifying C2/4GnT-coding exons by PCR, and detecting the prence of DNA quence variation are disclod.
申请人：グリコツイム エイピーエス
普通话口语训练60篇地址：デンマーク国、ホルテ、ノルスケ アレ 3
国籍：DK
代理人：浅村 皓 (外3名)
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