专利名称：HIGH CAMP YIELDING YEAST STRAIN AND
USE THEREOF
发明人：Shaolan ZOU,Wenxuan GAO,Yun HU,Shunhua
勤恳是什么意思YANG,Pingsheng MA
创卫工作计划申请号：US16094874
申请日：20160218
公开号：US20190390157A1
牵挂一个人的诗句公开日：
h英语
20191226
专利内容由知识产权出版社提供
童年的句子
专利附图：
种植葡萄
摘要：Provided is a yeast strain capable of excessively synthesizing cAMP and its
六画的字大全
construction method and fermentation technique thereof, and application in the field of
medicine, animal husbandry, food or chemical industry. The yeast strain includes first and cond gene modifications, wherein the first gene includes protein kina A (PKA) catalytic subunit encoding genes TPK1, TPK2 and TPK3, by modifying the first gene, the activity or expression of PKA is completely inhibited, so that feedback inhibition to cyclic adenosine monophosphate (cAMP) is eliminated, but at the same time, the growth of the yeast is inhibited; and the cond gene modification eliminates growth inhibition caud by the first gene modification, so that the yeast grows normally, and the cAMP yield by the yeast is incread, wherein the increa of the cAMP yield is relative to the cAMP yield by an unmodified yeast. The yeast strain further includes third and/or fourth gene modifications. The recombinant yeast strain of the prent invention can stably, continuously and efficiently produce extracellular cAMP by up to 9721.6 μmol/L.
业主大会
申请人：TIANJIN UNIVERSITY
地址：Tianjin CN
国籍：CN
更多信息请下载全文后查看
