专利名称：Amino acid lipids and us thereof
发明人：Quay, Steven,Houston, Michael,Harvie, Pierrot,Adami, Roger,Fam, Renata,Prieve,
Mary,Fosnaugh, Kathy,Seth, Shaguna
申请号：EP12158867.7
申请日：20080502
东湖梅园
公开号：EP2494993A3
祝阿姨生日快乐
公开日：
b岛
20121219
专利内容由知识产权出版社提供
摘要：The prent invention provides a compound comprising the structure shown in Formula I for u in delivering a therapeutic nucleic acid, one or more drug agents, or a biologically active agent to a cell, R-(C=O)-Xaa-Z-R Formula I wherein Xaa is histidine, 1-methylhistidine, pyridylalanine, lysine, arginine, homoarginine, nor-norarginine, ornithine, homolysine, asparagine, N ethylasparagine, glutamine, 4-aminophenylalanine, and nor-arginine, or an N-methylated version thereof; R is independently a lipophilic tail derived from a naturally-occurring or synthetic lipid, phospholipid, glycolipid, triacylglycerol, glycerophospholipid, sphingolipid, ceramide, sphingomyelin, cerebroside, or ganglioside, wherein the tail may contain a steroid; or a substituted or unsubstituted C(3-22)alkyl, C(6-12)cycloalkyl, C(6-12)cycloalkyl-C(3-22)alkyl, C(3-22)alkenyl, C(3-22)alkynyl, C(3-22)alkoxy, or C(6-12)alkoxy-C(3-22)alkyl; R is independently a lipophilic tail derived from a naturally-occurring or synthetic lipid, phospholipid, glycolipid, triacylglycerol, glycerophospholipid, sphingolipid, ceramide, sphingomyelin, cerebroside, or ganglioside, wherein the tail may contain a steroid; or a substituted or unsubstituted C(3-22)alkyl, C(6-12)cycloalkyl, C(6-12)cycloalkyl-C(3-
22)alkyl, C(3-22)alkenyl, C(3-22)alkynyl, C(3-22)alkoxy, or C(6-12)alkoxy-C(3-22)alkyl; wherein both R and R are lipophilic tails; and Z is NH, O, S, -CHS-, -CHS(O)-, or an organic linker consisting of 1-40 atoms lected from hydrogen, carbon, oxygen, nitrogen, and sulfur atoms; and salts thereof.
安卓短信
申请人：Marina Biotech, Inc.
地址：3830 Monte Villa Parkway Bothell, WA 98021-7266 US奶茶是怎么做的>男生生日祝福语
国籍：US
间变代理机构：Srinivasan, Ravi Chandran
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