Bacterial extract (OM-89) specific and non specific immunomodulation in rheumatoid arthritis patients.
期刊名称： Autoimmunity
天津比熊
作者： Toussirot, éric,Robinet, éric,Saas, Philippe,Chabod, Jacqueline, Augé, Beno?
t,Cozma, Gabriel,Tiberghien, Pierre,Roudier, Jean,Wendling, Daniel
年份： 2006年
期号： 第4期劳动英文>募捐感谢信
关键词： oral tolerance; heat shock protein; rheumatoid arthritis; T regulatory
cells; Interleukin-10
摘要：The Escherichia Coli bacterial extract (OM-89) is ud in the treatment of rheumatoid arthritis (RA). We evaluated the immunological changes induced by oral administration of OM-89 in 12 RA patients (polyclonal T cell reactivity to PHA, T cell precursor frequencies specific for OM-89 and Tetanu
s toxoid (TT), a control antigen and the relea of Th1 (IFN-, TNF-±), Th2 (IL-4) and T regulatory 1 cell (Tr1) (IL-10) cytokines in the supernatants of PBMC cultures. Stimulation index in respon to
克服自卑>关于夏天的句子PHA decread at month 3 as well as T cell precursor frequencies specific for TT
with similar trends for OM-89-specific T cell precursor frequencies. OM-89 induced
教案封面
班超投笔从戎a strong production of IL-10, a significant decrea in IL-4 production while TNF-±
and IFN- production tended to decrea during the study.
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