Test Non-Inferiority and Sample Size Determination Bad on the Odds Ratio Under a Cluster
流言止于智者Randomized Trial with Noncompliance 期刊名称： Journal of Biopharmaceutical Statistics托福报名网
撩妹小技巧作者： Kung-Jong Lui,Kuang-Chao Chang
年份： 2010年
梦开始的地方期号： 第1期
关键词： Cluster sampling; Dirichlet-multinomial model; Intraclass correlation;男孩的英语
Noncompliance; Non-inferiority; Odds ratio
摘要：Becau the odds ratio (OR) posss certain desirable statistical properties, the OR has been recommended elwhere to measure the relative treatment effect in establishing non-inferiority. For cost efficiency, we may often employ a cluster randomized trial (CRT), in which randomized units are clusters of patients. Furthermore, it is not uncommon to encounter data in which there are patients not
世界上最小的湖complying with their assigned treatment. Under the Dirichlet multinomial model, we have developed a test statistic for asssing non-inferiority bad on the OR between two treatments under a CRT with noncompliance. We
桑螵蛸的功效与作用学习的口号have further derived a sample size formula accounting for both noncompliance and the intraclass correlation for a desired power 1 of detecting non-inferiority with respect to the OR at a nominal ± level. Using
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