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Evaluation of urinary bladder cancer antigen as a marker for diagnosis of transitional cell carcinoma
of the urinary bladder.
期刊名称: Scandinavian Journal of Clinical & Laboratory Investigation
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vivox3t作者: Heicappell, R.
大国策年份: 2000年
期号: 第4期
关键词: carcinoma; transitional cell; diagnosis; tumor markers; biological
蜘蛛打野摘要:The purpo of the prent study was to asss a new quantitative urinary tumor marker for transitional cell carcinoma of the urinary bladder (TCC), measuring fragments of cytokeratin 8 and 18 in the urine (UBC). Urine samples of 355 individuals (77 healthy volunteers, 111 patients with benign urologic disorders, 167 patients with histologically proven bladder cancer) were examined for the pre
nce of UBC antigen. Samples of all patients were obtained prior to therapy. Compared to healthy volunteers or patients with benign urologic dia, patients with TCC had significantly higher median urinary levels of UBC antigen (0 vs. 4.18 vs.
7.46 microg/g creatinine; p<0.001, and p<0.01, respectively). UBC antigen levels were positively correlated with tumor grade and stage. Patients with invasive TCC had significantly higher levels
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