UnyLinker: An Efficient and Scaleable Synthesis of Oligonucleotides Utilizing a Universal Linker Molecule: A Novel Approach To Enhance the Purity
of Drugs
期刊名称： Organic Process Rearch & Development抗衰老护肤品
作者： Vasulinga T. Ravikumar,R. Krishna Kumar,Phil Oln,Max N. Moore,Sylvain Bernees
哈哈大笑的近义词年份： 2008年世界陆地最低点
荷花的词语期号： 第3期
关键词： MCR;multicomponent reaction;2-aminopyridine;microwave
鸡胸肉卷>林晓寓irradiation;naphthyridines;bismuth
摘要：A novel universal linker (UnyLinker) molecule which has a conformationally rigid and chemically stable bridge head ring oxygen atom carrying a conventional犯贱徐良
4,4′-dimethoxytrityl (DMT) and succinyl groups locked in a syn orientation has been developed to carry out oligonucleotide synthesis efficiently and smoothly. The geometry of the vicinal syn oxygen functionalized group allows fast and clean cleavage under standard aqueous ammonia deprotection conditions to afford high-quality oligonucleotides. No ba modification is obrved, bad on the ion-pair HPLC−UV−MS (IP-HPLC−UV−MS) method with detection limit of <0.1%. A class of impurities formed by branching from the exocyclic amino group of nucleosides loaded onto a solid support has been eliminated by the u of this method. Examples demonstrating the versatile nature
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十二生肖排名
