专利名称：METHOD OF DRUG LOADING IN LIPOSOMES BY GRADIENT
发明人：HU, Ning,JENSEN, Gerard, M.,SULIVAN,超市利润
Michele,YANG, Stephanie
申请号：US2003037790小学生好书推荐卡
申请日：20031126
花将
健康快乐歌公开号：WO04/047800P1
公开日：
20040610
专利内容由知识产权出版社提供
摘要：A method for encapsulation of pharmaceutical agents (e.g., antineoplastic agents) in liposomes is provided, having preferably a high drug:lipid ratio. Liposomes can be made by a process that loads the drug by an active mechanism using a transmembrane pH gradient. Using this technique, trapping efficiencies approach 100%. Drug:lipid ratios employed are higher than for older traditional liposome preparations, and the relea rate of the drug from the liposomes is reduced. After loading, residual acid is quenched with a quenching agent that is ba permeable at low temperatures. The residual aciditiy is thus reduced and chemical stability (e.g. against hydrolysis) is enhanced. The stability of both the liposome and the pharmaceutical agent is thus maintained, prior to administration. The pH gradient is, however, prent when the liposome is administered in vivo becau the quenching agent rapidly exits the liposome.红酒鸡翅
成绩英文申请人：HU, Ning,JENSEN, Gerard, M.,SULIVAN, Michele,YANG, Stephanie
地址：US,US,US,US,US
劲爆舞曲国籍：US,US,US,US,US
代理机构：MCCRACKIN, Ann, M.更多信息请下载全文后查看
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