超好听的女生网名The impact of assay recovery on the apparent permeability, a function of lysosomal trapping 期刊名称： Xenobiotica
作者： Dallas Bednarczyk,Menaka V Sanghvi
贵州古镇关键词： Lysosomal
头脑风暴英文>尿路感染治疗trapping;permeability;recovery;Papp;lysosome;MDCK;BCS;ECCS;EC3S
摘要：In vitro permeability asssment tools, like PAMPA, Caco-2, and MDCK, are frequently ud to asss permeability and provide input in to various classification systems. Frequently, the measured recovery values in permeability assays are poor. Poor recovery may be a result of lysosomal trapping of compound. It was hypothesized that a relationship existed between diminished assay recovery of compound due to lysosomal trapping and underestimation of the P app value. To examine this hypothesis, a ries of experiments were conducted measuring cellular accumulation, percent recovery, and permeability in the abnce or prence of an inhibitor of the V-type H+-ATPa, bafilomycin A1, to determine if a quantifiable relationship between lysosomal trapping, recovery, and permeability existed. Displacing
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