No. 90 East Zhongshan Road Tel:+86 25 84523390 84523391
Nanjing China Fax:+86 25 84520790 84520791
Zipcode: 210002 Email: ******************
3-O-ethyl ascorbic acid
No. 90 East Zhongshan Road Tel:+86 25 84523390 84523391
Nanjing China Fax:+86 25 84520790 84520791
Zipcode: 210002 Email: ******************
Catalogue
0. Structure Character (3)
1. Effectivity (4)
1.1 White effect (5)
1.2 The synthesis of collagen (5)
本草纲目的作者
本地游
1.3 Antioxidation (5)
1.4 Anti-inflammation (8)
1.5 Transportation to dermis (8)
2. Safety (8)
2.1 Toxicity (9)
2.2 Epidermis irritation test (9)
2.3 Eye irritation test (9)
3. Analytical Data (9)
3.1 General data (9)
3.2 Solubility (10)
4. Stability (10)
5. Usage (11)
5.1 U do (11)
5.2 U method (11)
5.3 U purpo (11)
5.4 U products (11)
6. Package (12)
7. Storage (12)
白垩7.1 Store method (12)
7.2 Store term (12)
8. Reference (12)
9. Formulation Example (13)
家居整理
No. 90 East Zhongshan Road Tel: +86 25 84523390 84523391 Nanjing China Fax:
+86 25 84520790 84520791 Zipcode: 210002 Email: ******************
O
CH
永定县
2
HO
CH
HO
O
OH
H
O CH 3CH
234
臭名远扬0. Structure Character
Chemical Name: 3-O-Ethyl Ascorbyl Ether English Name: 3-O-Ethyl Ascorbyl Ether INCI Name: Ethyl Ascorbic Acid Molecular Weight: 204.18 Molecular Formula: C 8H 12O 6 CAS No.: 86404-04-8 Chemical Structure:
早秋古诗Fig.1 The structure of 3-O-ethyl ascorbic acid
No. 90 East Zhongshan Road Tel:+86 25 84523390 84523391
Nanjing China Fax:+86 25 84520790 84520791
Zipcode: 210002 Email: ******************
1. Effectivity
3-O-ethyl ascorbic acid is an ethered derivative of ascorbic acid，the most excellent derivative of ascorbic acid so far. It is very stable in chemical structure, a real stable and discolored derivative of ascorbic acid, but also it can enter into skin and be metabolized by body as ascorbic acid. So its effect is better than pure ascorbic acid. 3-O-ethyl ascorbic acid is a unique lipophilic and hydrophilic material, easily ud in cosmetic formulation. The most important is that 3-O-ethyl ascorbic acid can easily enter into dermis and play biological effect, while pure ascorbic acid almost does not enter into dermis. 3-O-ethyl ascorbic acid is an excellent choice for cosmetic chemists.
The character of 3-O-ethyl ascorbic acid:
Excellent whitening effect: inhibit the activity of Tyrosina by act on Cu2+, prevent the synthesis of melanin（≥2%）
High antioxidation
Stable derivative of ascorbic acid
Lipophilic and hydrophilic structure
Anti-inflammation, inhibit the growth of bacteria
Improve the complexion, enhance the elasticity of skin.
Repair skin cells, accelerate the synthesis of collagen.
1.1 Whitening effect:
Generally speaking, ascorbic acid can inhibit the synthesis of melanin. But the effect of direct using ascorbic acid to skin is very bad. Clinical tests of human and animal prove: cosmetic product containing 2% can improve the complexion and whiten the skin. The mechanism is:瞧不起人的成语
1.1.1 Action one: deoxidize the oxided jet black melanin into tint melanin
1.1.2 Action two: inhibit the activity of Tyrosina, prevent the synthesis of melanin
No. 90 East Zhongshan Road Tel:+86 25 84523390 84523391
Nanjing China Fax:+86 25 84520790 84520791
Zipcode: 210002 Email: ****************** Reason: act with coenzyme Cu2+and weaken the activity of Tyrosina, avoid the formation of melanin
Table1 Inhibit the activity of Tyrosina
0.1% 0.5% 1.0% Ascorbic acid 96.7% 96.7% 97.6%
3-O-ethyl ascorbic acid 40.5% 89.4% 95.7% Magnesium ascorbyl phosphate 0% 4.9% 6.1%
Reduction of Inhibit the activity of
melanin Tyrosina
1.2 The synthesis of collagen
3-O-ethyl ascorbic acid can repair the activity of collagen (repair the structure and synthesis), improve the formation of skin cell and collagen according to the ratio of metabolic consumption. Its activity is similar to ascorbic acid phosphate derivative.
1.3 Antioxidation
1.3.1 antioxidation for oil
Cosmetic products contain plentiful oil, so they are easily oxidized by UV radiation, high temperature and humid atmosphere. When overdue or improperly stored, the products can be irritant to skin. T
herefore, cosmetic manufacturers usually add BHT, BHA and Tocopherol, etc. But the antioxidants are oil soluble and not easily metabolized by body. 3-O-ethyl ascorbic acid is a high effective lipophilic and hydrophilic antioxidant, it can decrea the occurrence of oil oxidation, and prevent cosmetics deteriorate.
