分类号：密级：
UDC：学号：************
搞笑歇后语大全南昌大学专业学位硕士研究生
学位论文
妊娠期急性胰腺炎的危险因素分析及NLR、血糖对
其诊断价值的探讨
柴夫Analysis of risk factors and discussion of the diagnostic value of NLR and blood gluco in acute pancreatitis in
pregnancy
陈晓青
培养单位（院、系）：南昌大学第一附属医院
指导教师姓名、职称：余筱琳主任医师
专业学位种类：临床医学硕士
专业领域名称：妇产科学
论文答辩日期：2020年6月
答辩委员会主席：朱清仙
评阅人：傅芬
郑九生
2020年6月
摘要
摘要
目的：
回顾性分析南昌大学第一附属医院妊娠期急性胰腺炎（acute pancreatitis in pregnancy,APIP）患者的临床资料，对其血脂、血糖、血钙、中性粒细胞绝对值及淋巴细胞绝对值进行分析，探讨APIP的独立危险因素；探讨中性粒细胞与淋巴细胞比率（NLR）及血糖对APIP的诊断价值。
方法：
回顾性收集南昌大学第一附属医院2014年01月至2019年09月确诊为妊娠期急性胰腺炎且就诊前未予治疗的患者61例作为实验组，随机纳入同时期年龄及孕周相近的正常妊娠孕妇为对照组，收集两组研究对象一般资料及相关生化检验指标，通过统计学分析，对比两组甘油三酯、胆固醇、高密度脂蛋白、低密度脂蛋白、血糖、血钙及NLR，对可能导致APIP的危险因素进行多因素logistic回归分析，探讨APIP的独立危险因素；运用受试者工作特征曲线（ROC曲线）评估NLR及血糖对APIP的诊断价值。
抗抑郁药有哪些
结果：
秋日物语APIP多发生于妊娠中晚期，占95.08％，主要病因为高脂血症（52.46％）及胆道疾病（36.07％），其中高脂血症以甘油三酯升高多见。APIP患者甘油三酯、胆固醇及血糖均高于正常妊娠孕妇，而高密度脂蛋白、低密度脂蛋白、血钙则低于正常妊娠孕妇。甘油三酯、胆固醇、高密度脂蛋白、低密度脂蛋白及血糖差异存在统计学意义（P＜0.05），血钙差异无统计学意义。
APIP患者与正常妊娠孕妇相比，中性粒细胞绝对值及NLR增高，而淋巴细胞绝对值降低，差异均存在统计学意义（P＜0.05）。
ROC曲线显示，NLR及Glu对APIP均有一定的诊断价值，且具有较高的灵敏度及特异度。NLR的诊断价值较Glu高，其截断值为6.6172，灵敏度为90.2％，特异度为94.3％。血糖截断值为5.6650，灵敏度为77.0％，特异度为76.2％。幼儿园自制玩具
滑冰技巧结论：
1.妊娠期血脂或血糖升高可使APIP发病率增加，APIP常伴有甘油三酯、
II
摘要
胆固醇、血糖及血钙指标的异常，高甘油三酯为APIP的独立危险因素，高血糖可能为APIP的独立危险因素。
2.NLR作为炎性指标之一，在APIP发生时升高，对APIP可能具有一定的诊断价值。
3.血糖在APIP发生时升高，其对诊断APIP可能具有一定的价值。
关键词：APIP；血脂；血糖；NLR；诊断价值
建筑劳务合同
III
Abstract
ABSTRACT
Objective:
we retrospective analyzed the clinical data of patients with acute pancreatitis in pregnancy(APIP)in the First Affiliated Hospital of Nanchang University.Blood lipid, blood gluco,blood calcium,neutrophil absolute value and lymphocyte absolute value were analyzed to explore the inde
pendent risk factors of APIP；we discusd the diagnostic value of neutrophil to lymphocyte ratio(NLR)and blood gluco in APIP.
佛手柑油Methods:
We collected61patients with acute pancreatitis in pregnancy who had not been treated before treatment in the First Affiliated Hospital of Nanchang University from January2014to September2019.The normal pregnant women with similar ages and gestational weeks in the same period were randomly included as the control group, collecting the general data and relevant biochemical test indexes of the two groups, Through statistical analysis,the triglycerides,cholesterol,high-density lipoprotein, low-density lipoprotein,blood gluco,blood calcium and NLR of the two groups were compared,and the possible risk factors of APIP were analyzed by multi factor Logistic regression analysis to explore the independent risk factors of APIP.The ROC curve was ud to evaluate the diagnostic value of NLR and blood gluco in APIP. Results:
APIP mostly occurred in the middle and late pregnancy,accounting for95.08%. The main caus of APIP were hyperlipidemia(52.46%)and biliary tract dia (36.07%).Hyperlipidemia is more common with elevated triglycerides.Triglyceride, cholesterol and blood gluco of APIP patients wer
e higher than tho of normal pregnant women,while HDL,LDL and blood calcium was lower than that of normal pregnant women.There was statistical significance in the difference of triglyceride, cholesterol,HDL,LDL and blood gluco(P>0.05).There was no statistical significance in the difference of blood calcium.
IV
