画水母
Nectin1 expression is frequently decread in gastric cancers: Nectin1 less expresd in gastric
cancers
期刊名称： Pathology International
古代公主等级
作者： Takahashi, Yu,Yamamichi, Nobutake,Inada, Ken-ichi,Shiogama,
Kazuya,Sakurai, Kouhei,Takeuchi, Chihiro,Mizutani, Yasuyoshi,Tsutsumi,
收入模式
Yutaka,Koike, Kazuhiko
卡利乌斯
年份： 2018年
长江社区>一条鱼水里游期号： 第10期
关键词： gastric cancer;histological pattern;nectin1
古风句子摘要：Gastric cancer (GC) is rich in many different histological types, but how the histological pattern i
s defined remains to be proved. The relation between GC histological types and the expression of nectin1, which is one of the cell adhesion molecules that compos adherens junction, has not been reported. According to a publicly available databa of 406 GC patients, the median overall survival of Nectin1 high expression patients was 55.4 months and that of low expression patients was 25.6 months ( P = 0.0246). Using surgically or endoscopically rected GC samples, nectin1 expression was analyzed by immunohistochemistry. Nectin1 expresd at adherens junction in all the normal epithelial cells. However, nectin1 expresd not at adherens junction but at apical membrane in epithelial cells in intestinal metaplasia. The
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