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三步交谊舞>孕妇能吃花椒不
Carbamazepine-induced cutaneous reactions: a simple assay to identify patients carrying the HLA-
A*31:01 allele.
期刊名称： Scandinavian Journal of Clinical and Laboratory Investigation
作者： Ketil Thorstenn,Mona Kvitland,Maryam Shirzadi,Grethe Helde,Eylert
孕晚期可以泡脚吗Brodtkorb
低调图片年份： 2014年
蓝牙耳机排行榜10强期号： 第7期
关键词： Adver cutaneous reactions;CBZ;Marker;Single nucleotide
polymorphism酱拌面
摘要：Aims. Treatment with the first-line antiepileptic drug, carbamazepine (CBZ), is associated with a
dver cutaneous reactions in up to 10% of patients. One predisposition to the side-effects has been linked to the HLA-A*31:01 allele. HLA-typing is costly and time-consuming. A single nucleotide polymorphism (SNP,
rs1061235A > T) has been suggested as a marker for the HLA-A*31:01 allele. We sought to develop and validate a simple, fast and inexpensive assay for rs1061235
七夕音乐to apply in the Norwegian population. Methods. We designed a polymera chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay for the SNP and tested it on a t of 16 samples with known HLA-A alleles. Results. The assay identified all HLA-A*31:01 alleles prent, but also marked for HLA-A*33:03. In a cond t of 204 samples from
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