调薪申请表
Mitophagy is primarily due to alternative autophagy and requires the MAPK1 and MAPK14
signaling pathways
期刊名称： Autophagy
作者： Hirota, Yuko, Yamashita, Shun-ichi, Kurihara, Yusuke, Jin, Xiulian, Aihara, Masamune, Saigusa, Tetsu, Kang, Dongchon, Kanki, Tomotake
年份： 2015年
期号： 第2期
关键词： autophagy;alternative autophagy;Keima;mitochondria;mitogen-
自力更生意思
activated protein kina;mitophagy;3-MA, 3-methyladenine;ATG, autophagy-
必读书籍排行榜related;CCCP, carbonyl cyanide m-chlorophenyl hydrazone;ER, endoplasmic
泡红茶的水温reticulum;FUNDC1, FUN14 Domain Containing 1;LC3, microtubule-associated
protein 1 light chain 3;MAPK, mitogen-activated protein kina;MEF, mou
张敬轩的歌embryonic fibroblast;MEK, MAPK-ERK kina;MKK, MAP kina kina;PE,
情侣主
phosphatidylethanolamine;PINK1, PTEN-induced putative kina protein 1;PTEN, phosphata and tensin homolog;siRNA, short interfering RNA;SQSTM1,
questosome 1;Tet, tetracycline
乘虚而入的意思
摘要：In cultured cells, not many mitochondria are degraded by mitophagy induced by physiological cellular stress. We obrved mitophagy in HeLa cells using a method that relies on the pH-nsitive fluorescent protein Keima. With this approach, we found that mitophagy was barely induced by carbonyl cyanide m-chlorophenyl hydrazone treatment, which is widely ud as an inducer of
PARK2/Parkin-related mitophagy, whereas a small but modest amount of mitochondria were degraded by mitophagy under conditions of starvation or hypoxia. Mitophagy induced by starvation or hypoxia was marginally suppresd by
雪肤莱
knockdown of ATG7 and ATG12, or MAP1LC3B, which are esntial for conventional macroautophagy. In addition, mitophagy was efficiently induced in Atg5 knockout mou embryonic fi
broblasts. However, knockdown of RAB9A and RAB9B, which
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