Agilent 6550 iFunnel Q-TOF LC/MS System Breakthrough
Technology iFunnel
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Unmatched speed and nsitivity for your most challenging qualitative and
quantitative analys in a single instrument
Agilent 6550 iFunnel Q-TOF LC/MS System
Incorporating breakthrough Agilent iFunnel technology, the Agilent 6550 iFunnel Q-TOF LC/MS system delivers the lowest detection levels of any high resolution LC/MS instrument. For the fi rst time ever, you can achieve low femtogram-level nsitivity with high resolution and accurate-mass—making the 6550 iFunnel Q-TOF the ideal choice for pharmaceutical,
metabolite ID, discovery proteomics, metabolomics, food safety, forensics, toxicology, and environmental screening applications.
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Agilent Ion Beam Compression and Shaping (IBCS) technology provides the greatest nsitivity while maintaining 40k mass resolution and sub 1-ppm mass accuracy. Enhanced electronics and software algorithms enable exceedingly high data acquisition rates of up to 50 spectra/cond for ultra-fast UHPLC parations with the Agilent 1290 Infi nity LC and for maximum sampling during data-dependent MS/MS experiments.
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The Agilent 6550 iFunnel Q-TOF LC/MS delivers the lowest limits of detection over the widest in-spectral dynamic range—in a benchtop system.
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Agilent Ion Beam Compression and Shaping (IBCS) technology compress and cools the ion beam up to 10-fold, resulting in fewer ion loss and more preci mass measurement . Achieve 40K mass resolution and low femtogram nsitivity simultaneously.
Revolutionary iFunnel technology combines Agilent Jet Stream technology, a hexabore sampling capillary and a dual stage ion funnel to dramatically increas ion transmission for greatly improved nsitivity .
Ions are accelerated in the collision cell to enable faster generation of high-quality MS/MS spectra.
Proprietary INVAR fl ight tube aled in a vacuum-insulated shell eliminates thermal mass drift due to temperature changes to maintain excellent mass accuracy, 24/7. Added length improves mass resolution .
Modern electronics
enable a fast acquisition rate of 50 spectra/c. 4GHz digitizer enables a high sampling rate (32 Gbit/s) to improve the resolution, mass accuracy, and nsitivity for low-abundance samples. Dual gain amplifi ers extend the dynamic range to 105.
Agilent’s proprietary iFunnel technology combines the high-effi ciency ESI ion generation and focusing of Agilent Jet Stream sample introduction with unique hexabore sampling capillary and dual stage ion funnel asmblies. This innovative technology demonstrates double-digit increas in nsitivity compared to older instruments.
Agilent iFunnel technology provides a level of robustness unmatched in the industry by combining true orthogonal electrospray orientation with a heated, off-axis funnel geometry to prevent transmission of uncharged species.
Three technological innovations work together to reduce contamination, and dramatically improve overall signal within the system:
Agilent Jet Stream thermal gradient focusing —A precily micro-machined
sprayer surrounds ESI droplets with a sheath of superheated gas to desolvate and concentrate ions near the MS inlet for more effective sampling.
H exabore sampling capillary —Six independent, parallel bores enable
red stonea much larger fraction of the ions formed in the ESI spray plume to enter the mass spectrometer.
Dual-stage ion funnel —Novel design facilitates incread ion transfer to Q1
while evacuating the higher gas load.
To learn more about the Agilent 6550 iFunnel Q-TOF LC/MS system, visit /chem/qtof 3
“Ion Funnel technology could possibly be the most signifi cant MS development since the introduction of the API. It delivers a fundamental nsitivity and detection limit breakthrough—resulting in performance far exceeding the capabilities of conventional mass spectrometers.”
Dr. Richard Smith Inventor of the Ion Funnel, Battelle Fellow and Chief Scientist, PNNL
iFUNNEL TECHNOLOGY REVOLUTIONIZES
ATMOSPHERIC SAMPLING
Counts vs. Mass-toCharge (m/z)
120 160 200 240 280 320 360 400
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2 –
1 –
0 –
x104
122.0713C 6H 8N 3
0.07 ppm
150.1023C 8H 12N 3-2.01 ppm
178.1212
C 9H 14N 4
-0.39 ppm
238.1439
C 13H 20NO3-0.68 ppm 281.1859
C 15H 25N 2O 3
-0.41 ppm
402.2499
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The new 6550 iFunnel Q-TOF with high nsitivity and mass-accuracy enables (Figure A) accurate, linear
quantitation of buspirone in complex matrix down to low pg/mL concentrations, (Figure B) high quality, accurate-mass MS/MS spectrum of a metabolite, buspirone monohydroxy metabolite, with sub-ppm mass accuracy on both precursor and fragment ions for confi dent metabolite identifi cation, and (Figure C) metabolic stability and metabolite profi ling in rat liver microsomal incubation illustrating complete coverage of major and low level metabolites
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R e s p o n s e s
Concentration ng/ml
0 1 2 3 4 5 6 7 8 9 10
5 –
4 –
3 –
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x106
R 2=0.999
Pharmaceutical Rearch
Ultra-nsitive performance in the most critical Qual/Quan applications
Imagine combining the quantitative requirements of metabolic stability testing and metabolite profi ling with the qualitative requirements of metabolite identifi cation – all in a single instrument. This has been realized with the new 6550 iFunnel Q-TOF. The dramatically enhanced nsitivity of this new s
ystem facilitates accurate quantifi cation of parent drug and metabolites at levels well below tho previously attainable with a high resolution, accurate mass LC/MS system. The system is ideally suited for metabolic stability and profi ling studies, combining the highest nsitivity to detect compounds at low pg/mL levels, with 40k resolving power and excellent mass and isotope accuracy for confi dent identifi cation of metabolites.
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Counts vs. Acquisition Time (min)
8 8.5 9 9.5 10 10.5
3 –
2 –
1 –
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x105
9.291
382 383 384 385 386 387 388
384.1415
384.1454
386.1495
contribute2 –
1 –
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x10Food Safety
Screen and identify pesticide residues with unsurpasd speed and nsitivity
To assure food safety, robust methods are needed to rapidly screen samples for a large number of pesticides and other undesirable contaminants at ultra-trace levels. Unparalleled accuracy in mass measurements and isotope abundance make Q-TOF LC/MS systems the ideal choice for detection and identifi cation of both targeted and non-targeted pesticides. The unsurpasd nsitivity of the 6550 iFunnel Q-TOF LC/MS system facilitates detection and quantitation of trace level compounds, allowing labs to keep pace with evolving regulations and to confi dently identify new, emerging contaminants.
初二政治上册知识点>发呆英文While the international action level for pesticide residues in fruit and vegetables is 10 ppb, a recent study by the European Reference Laboratory (Almeira, Spain) showed that 15% of the pesticide compounds tested with a previous generation Q-TOF could only achieve detection limits of 20 to 100 ppb. Using the dramatic nsitivity gains of the new Agilent 6550 iFunnel Q-TOF, a signifi cant improvement in detection limit was demonstrated for the majority of the compounds to less than 1
0 ppb — including many of the least responsive pesticides.
To learn more about the Agilent 6550 iFunnel Q-TOF LC/MS system, visit /chem/qtof For pesticide analysis, the 6550 iFunnel Q-TOF demonstrated (Figure A) 10-fold nsitivity gain for a poor responding pesticide
(fl uazifop-butyl) in pepper matrix. Extracted ion chromatogram shows excellent detection (S/N 1200) on 10 ppb fl uazifop-butyl and (Figure B) confi dent compound identifi cation of fl uazifop-butyl with an excellent library match score of 98 bad on a mass error of only 0.5 ppm and correct fi t of isotope abundance and spacing.
