专利名称：PSMA antibody-drug conjugates
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发明人：Dangshe Ma,Paul J. Maddon,William C.mony
Olson,Svetlana O. Doronina,Brian E.
Toki,Peter D. Senter
申请号：US11471457音标单词
申请日：20060620
公开号：US20070160617A1
公开日：
20070712
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专利附图：
shinshin摘要：This invention relates generally to antibody-drug conjugates (ADCs). In
哲布尊丹巴particular, the invention relates to ADCs which compri an antibody or antigen-binding fragment thereof which binds to prostate-specific membrane antigen (PSMA) and is conjugated to monomethylauristatin norephedrine or monomethylauristatin
not at all什么意思phenylalanine. The antibody-drug conjugate has a PC-3™ cell to C4-2 or LNCaP™ cell lectivity of at least 250. The invention also relates, in part, to compositions of and methods of using the ADCs. The methods provided include, for example, methods for treating a PSMA-mediated dia.强度英文
申请人：Dangshe Ma,Paul J. Maddon,William C. Olson,Svetlana O. Doronina,Brian E.Toki,Peter D. Senter
地址：Millwood NY US,Scarsdale NY US,Ossining NY US,Snohomish WA US,Shoreline WA US,Seattle WA US
国籍：US,US,US,US,US,US
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