Rational site-directed pharmacotherapy for major
跻身于depressive disorder
期刊名称： International Journal of Neuropsychopharmacology
erotic>软件本地化作者： Blier Pierre
guerny>blh
可圈可点试题网年份： 2014年from the heart
亵渎的意思期号： 第7期
关键词： Antidepressants;atypical antipsychotic;drug
combination;monoamines;polypharmacy
摘要：It is now accepted that major depressive disorder (MDD) is not a single pathophysiological entity. It is therefore not surprising that remission rates to a first antidepressant trial are low. In addition, antidepressants may target various neuronal elements for which there are gene polymorphisms, such telon
从小事做起 英语as the rotonin (5-HT) reuptake transporter, which may modulate respon. Acting on a single monoaminergic target, such as inhibiting the 5-HT transporter, may confer efficacy in MDD, but other targets may be ud and/or combined in treatment-resistant patients. The include the blockade of norepinephrine transporters, monoamine oxida, 5-HT(2A), 5-HT(1B) and 5-HT7 receptors, and the activation of 5-HT(1A) and dopamine 2 receptors. While antidepressants may have more than one of the properties, so do atypical antipsychotics.
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