Intracellular signaling pathways pave roads to recovery for mood disorders
purple怎么读期刊名称： Annals of Medicineraw
玻璃杯的英语
rubber duck作者： Tanis, Keith Q.,Duman, Ronald S.
catalogue英语广场年份： 2007年
期号： 第7期手榴弹英文
关键词： antidepressive agents; bipolar disorder; cyclic AMP respon element-binding protein; depression; extracellular signal-regulated AMP kinas;
glycogen syntha kinas; inositol; norepinephrine; rotonin
glu抛出窗外摘要：Mood disorders, including major depression and bipolar disorder, remain a major unmet medical need as current antidepressant and mood stabilizing therapies require chronic treatment for efficacy and are not effective in all patients. Multiple deficits, including cell atrophy and loss, have been obrve
d in limbic and cortical brain regions of patients with mood disorders and in stresd animals. It is thought that antidepressant and mood stabilizing medications restore the deficits by reestablishing proper patterns of gene expression and function. In support of this hypothesis, numerous changes in gene expression and activity have been obrved in limbic and cortical brain regions of mood disorder patients, and thymoleptic therapies have been shown to reciprocally regulate many of the changes. The findings have implicated
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