floodRegression Analysis of Fold-Increa Endpoints Using a Distributional Approach for Paired Interval-blonde是什么意思
注册会计师教材Censored Antibody Data
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期刊名称： Statistics in Biopharmaceutical Rearch
作者： Yin Bun Cheung,Xiangmei Ma,K. F. Lam
年份： 2018年
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期号： 第3期
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副局长英文关键词： Antibody titers;Covariate adjustment;Dichotomization;Distributionalwww etest edu cn
you to beapproach;Interval-censoring;Risk ratio
摘要：Biopharmaceutical rearch often us a binary "fold-increa" respon variable defined by the ratio of a pair of interval-censored measurements taken at baline and end-of-study. Conventional practice ignores the interval-censoring nature of the data. Moreover, conventional practice dictates that
the possible choices for cut-off to define the respon must follow a geometric quence. A novel method bad on the "distributional approach" was propod for the analysis of such paired measurements in a randomized trial context. The degree of fold-increa above which a respon is defined can be chon according to scientific rationale instead of being limited to a geometric quence. The risk ratio is then estimated for comparison between trial arms. We extend the method to allow for adjustment for baline covariates in
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