CXCR4-targeted PET imaging using 64Cu-AMD3100 for detection of Waldenström Macroglobulinemia 期刊名称： Cancer biology & therapy
作者： Barbara Muz,Nilantha Bandara,Cedric Mpoy,Jennifer Sun,Kinan清华姚班是什么
kingwood
primark>交互英语2答案Alhallak,Feda Azab,Buck E. Rogers,Abdel Kareem Azab
年份： 2019年
顶艺法语
期号： 第1期
关键词： Lymphoma;Waldenström Macroglobulinemia;hypoxia;PET
英语单词不用记imaging;metastasis
摘要：Objective : Waldenström Macroglobulinemia (WM) is a rare B-cell malignancy characterized by cretion of immunoglobulin M and cancer infiltration
in the bone marrow. Chemokine receptor such as CXCR4 and hypoxic condition in靠边停车技巧
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the bone marrow play crucial roles in cancer cell trafficking, homing, adhesion, proliferation, survival, and drug resistance. Herein, we aimed to u CXCR4 as a potential biomarker to detect hypoxic-metastatic WM cells in the bone marrow and卤素
in the circulation by using CXCR4-detecting radiopharmaceutical. Methods : We radiolabeled a CXCR4-inhibitor (AMD3100) with 64Cu and tested its binding to WM cells with different levels of CXCR4 expression using gamma counter in vitro . The accumulation of this radiopharmaceutical tracer was tested in vivo in subcutaneous and intratibial models using PET/
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