Sharpless不对称胺基羟基化反应
在锇催化下胺基和羟基对烯烃进行顺式加成,通过加入手性配体(二氢奎宁或二氢奎宁衍生物类手性配体)实现对映选择性。常见的氮源(XNClNa)包括:
反应机理:
催化循环(跟更多机理的详细介绍,请回复“Sharpless胺基羟基化反应”,回看往期内容)
反应实例
参考文献一月的英文
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Sharpless (USA, 1941) shared the Nobel Prize in Chemistry in 2001 with Herbert
William S. Knowles (USA, 1917) and Ryoji Noyori (Japan, 1938) for his work on
chirally catalyzed oxidation reactions. (b) Li, G.; Angert, H. H.; Sharpless, K. B.
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2013高考语文试卷7. Bolm, C.; Hildebrand, J. P.; Muñiz, K. In Catalytic Asymmetric Synthesis; 2nd edn., Ojima, I., Ed.; Wileymy spring festivalVCH: New York, 2000, 399. (Review).
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编译自:Name Reactions (A Collection of Detailed Reaction Mechanisms), Jie Jack Li, Sharpless asymmetric amino-hydroxylation,page 546-548.