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The roles of cell adhesion molecules in tumor suppression and cell migration: A new paradox 期刊名称： Cell Adh Migr
作者： Moh, Mei Chung,Shen, Shali北京英语班费用
年份： 2009年
职称外语
晚安日语期号： 第4期服装搭配学校
原来如此日文
strat关键词： Humans;Cell Adhesion Molecules;Tumor Suppressor
Proteins;Neoplasm Invasiveness;Cell Movement
leavealone摘要：In addition to mediating cell adhesion, many cell adhesion molecules act as tumor suppressors. The proteins are capable of restricting cell growth mainly through contact inhibition. Alterations of the cell adhesion molecules are a common event in cancer. The resulting loss of cell-cell and/or cell-extracellular matrix adhesion promotes cell growth as well as tumor dismination. Therefore, it is conventionally accepted that cell adhesion molecules that function as tumor suppressors are also invol
ps i love youved in limiting tumor cell migration. Paradoxically, in 2005, we identified an immunoglobulin superfamily cell adhesion molecule hepaCAM that is able to suppress cancer cell growth and yet induce migration. Almost concurrently, CEACAM1 was verified to co-function as a tumor suppressor and invasion promoter. To date, the reason
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