建造师培训ATP-Dependent Chromatin-Remodeling Complexes in DNA Double-Strand Break Repair: Remodeling,
Pairing and (Re)pairing
期刊名称： Cell cycle (Georgetown, Tex.)
作者： Huang, Jian,Liang, Bing,Qiu, Jiajing,Laurent, Brehon C.
上海十大最乱学校年份： 2005年儿童节快乐的英语
期号： 第12期
关键词： Animals;Chromatin;Multiprotein Complexes;Adenosine
classified post
beautiful dayTriphosphate;Chromosome Pairing;Chromatin Asmbly and
Disasmbly;Adenosine Triphosphatas;DNA Damage;DNA Repair
摘要：The genomic integrity of a eukaryotic cell is challenged by over 10,000 chromosomal lesions perday. Therefore the cell has evolved efficient mechanisms
八年级下册英语单词>不给力英文
to recognize, signal, and repair DNAbreaks. Defects in any of the steps can leadfleshy
美国文学
2014网络流行语to chromosomal aberrations and cancers. As thelesions must be repaired in the context of chromatin, both chromatin-modifying and nucleosomeremodelingenzymes have been implicated in DNA damage repair. We reported recently that theRSC and Swi/Snf ATP-dependent chromatin-remodeling complexes are involved in DSB repairspecifically by homologous recombination. Here we discuss how such enzymes might be recruitedto DNA breaks, why so many remodelers are recruited to sites of DSBs, and a possible functionalconnection between RSCs roles in sister chromatid cohesion and DSB repair.
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