专利名称：ANTIVIRAL AGENTS AND VACCINES
AGAINST INFLUENZA
发明人：NABEL, Gary, J.,KONG, Wing-pui,YANG, Zhi-yong,TUMPEY, Terrence
置若罔闻申请号：US2007004506卖场布局>knicks
申请日：20070216
公开号：WO07/100584P1
公开日：coupons
shrimp
盘缠
泥淖20070907
专利内容由知识产权出版社提供
摘要：The vaccines target H5N1, H1, H3 and other subtypes of influenza and are designed to elicit neutralizing antibodies, as well as cellular immunity. The DNA vaccines express hemagglutinin (HA) or nucleoprotein (NP) proteins from influenza which are codon optimized and/or contain modifications to protea cleavage sites of HA which affect the normal function of the protein. Adenoviral constructs expressing the same inrts have been engineered for prime boost strategies. Protein-bad vaccines bad on protein production from inct or mammalian cells using foldon trimerization stabilization domains with or without cleavage sites to assist in purification of such proteins have been developed. Another embodiment of this invention is the work with HA pudotyped lentiviral vectors which would be ud to screen for neutralizing antibodies in patients and to screen for diagnostic and therapeutic antivirals such as monoclonal antibodies.
申请人：NABEL, Gary, J.,KONG, Wing-pui,YANG, Zhi-yong,TUMPEY, Terrence套房英文
地址：National Instit AND HUMAN SERVICES Office of Techn 6011 Executive Blvd., Suite 325 Rockvillle, Maryland 20852-3804 US,Centers for Dia Control and Prevention
iman4770 Buford Hwy (K79) Atlanta, Georgia 30333 US,2520 30th Street, NW Washington, District Of Columbia 20008 US,13308 Copper Ridge Road Germantown, Maryland 20874 US,10004 Penfold CT Potomac, Maryland 20854 US,970 Pebble Bend Drive Grayson, Georgia 30017-1560 US
国籍：US,US,US,US,US,US
代理机构：DELANEY, Karoline, A.
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