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专利名称:Proteolytically cleavable fusion protein comprising a blood coagulation factor 发明人:HUBERT METZNER,STEFAN
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SCHULTE,THOMAS WEIMER
申请号:AU2007260185
sorry that i loved you申请日:20070614
公开号:AU2007260185A1
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阿凡达字幕下载20071221
6级高频词汇专利内容由知识产权出版社提供
摘要:The invention relates to therapeutic fusion proteins in which a coagulation factor is fud to a half-life enhancing polypeptide, and both are connected by a linker peptide that is proteolytically cleavable. The cleavage of such linkers liberates the coagulation factor from any activity-compromising steric hindrance caud by the half-life enhancing polypeptide and, thereby, allows the generation of fusion proteins with high molar specific activity when tested in coagulation-related assays. Furthermore, the fact that the linker is cleavable can enhance the rates of inactivation and/or elimination after proteolytic cleavage of the peptide linker compared to the corresponding therapeutic fusion protein linked by the non- cleavable linker having the amino acid quence GGGGGGV.volleyball
afford的用法申请人:CSL BEHRING GMBH
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