Role of TLR4 in the induction of inflammatory changes in adipocytes and macrophages 期刊名称： Adipocyte
权限英文takemehomecountryroad作者： K. McKernan,Mita Varghe,R. Patel,K. Singertowie
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年份： 2020年
期号： 第1期衣橱的英文
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关键词： Toll-like receptors;inflammation;adipo tissue
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macrophages;adipogenesis;ear menchymal stem cells;bone marrow derived dendritic cells;lipopolysaccharide;saturated fatty acids;cytokineson the line
摘要：In obesity, high levels of saturated fatty acids (SFAs) contribute to adipo tissue inflammation and dysfunction. Obesity-induced macrophage infiltration leads to insulin resistance, but the adipocyte itlf may play a role in generating the inflammatory milieu. Given our recent findings of the role of TLR4 in myeloid biasing in obesity, we next investigated the role of TLR4 in adipocyte generated inflamprettyboy是什么意思
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matory respons to SFAs and lipopolysaccharides. We ud WT and ear menchymal stem cell derived adipocytes (EMSC Ad) and bone marrow dendritic cells (BMDCs) to evaluate cell specific respons. Our work demonstrates a role for TLR4 in adipocyte- immune cell crosstalk and that SFA derived metabolites from adipocytes may induce proinflammatory stimulation of immune cells in a TLR4 independent manner.
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