第44卷第6期
cities是什么意思
2217年6月贵州医科大学学报
Vol. 44 No. 6JOURNAL OF GUIZHOU MEDICAL UNIVERSITY 2217.4郑州一八联合国际学校
heka糖通饮对糖尿病肾病大鼠肾脏保护作用* ** ［基金项目］贵阳市人民政府-贵州医科大学科学技术联合基金(GY2012-21)
* *通信作者 E-mail ：1052177563@qu. com
长沙新东方英语网络出版时间：2019 -06 -22 网络出版地址：ktw ：//kks. cedi. ket/kcms/ketWP /k2.1124. R. 22120622. 2703.210 kwi
不过如此的意思高楠楠3侯胜开3屈璐3潘艳伶04…
(1.贵州医科大学临床医学院中医学教研室，贵州贵阳550024； 0.贵州医科大学贵州省常见慢性疾病发病机制及药物研究重点实验 室，贵州贵阳550225)
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［摘 要］目的：探讨糖通饮对早期糖尿病肾病大鼠肾脏组织的保护作用。方法：雄性SD 大鼠55只，随
机分 为正常组(A 组)10只，剩余的45只造模，将造模成功的44只SD 大鼠分为模型组(B 组)、糖通饮组(C 组)、厄 贝沙坦组(D 组)及糖通饮+厄贝沙坦组(E 组)，每组10只；C 、D 、E 组给予对应的药物灌胃治疗,A 组及B 组给 予等量生理盐水灌胃2周末检测大鼠的空腹血糖(FBG )、血清肌0( SCP 及24 h 尿蛋白定量，取右侧肾脏苏木 精-伊红(HE )染色光镜下观察组织学改变。结果：与A 组比较,B 组大鼠肾脏病理形态变化明显,FBG 、SCr 及 20。尿蛋白明显升高，差异有统计学意义(P<0.05)；与B 组比较，C 、E 组的FBG 、SCr 及24 h 尿蛋白明显降 低,D 组的SCr 及24 h 尿蛋白明显降低，差异有统计学意义(P<0.05)；与B 组比较,C 、D 、E 组治疗后病理改变 均明显减轻。结论：糖通饮能够有效地减少早期DN 大鼠的24 h 尿蛋白，降低FBGp SCr 水平，对大鼠肾脏组 织 有 护 用。allegorical
［关键词］糖尿病肾病；糖通饮；厄贝沙坦；尿蛋白；血清肌O ；病理学
［中图分类号］R587.1；R282 ［文献标识码］A ［文章编号］1000-2707(2019)06-0675-65DOI 40.19367/j. chkl. 1000-2707. 2012.06.011
Siidy on the Prdtective 已展厲：of Tangtong Drink on Kidney
in Rats wii Diabetit Nephrdpathy
GAO Nannon 1 , HOU Shengka/ , QU Lu 1 , PAN YanPng 12pocket pc
whateveryoudo
(1. Department U Traditiouat Chine Menicine , School U Climcal Medicine , Guizhou Medicat University , Guiyarn 550004,
Guizhou , Chirm ； 2. Guizhou P tu HI Ke, Laborator) U Pamouesie & Grug Rearch ou Commou Chronic
Dias , Guizhou Menical University , 6x 01-550025 , Guizhou , Chim -2016年考研国家线
［AbsOdcS ］ Objective : To investigato thv putective effects of Tangtong Dunk ox kibni tissuo of rats with exr-o diaUetIc 5iPup/Uy. Methods ： A total of 55 mala SpuguiNdwDy rats were unhomty dl- vibeh into kounat (A ) guxp (n 二 12) , and thv remaining 45 rats were modeDh. 44 SD rats with suc- cessfut modeling were divibeh ienty into model ( B ) guxp , Tanytoxy Dunk ( C ) Guxp , IrdesaUon (D ) guxp , and Tanytoxy Dunk + IrdesaUon ( E ) guxp. Guxp C , D , and E were given thv corro- spodhing duns for intragastkc akministratiox , and guxp A and guxp B were given thv sama amornt of nounat sa/no. AUor 5 wihs, thv fasting blood gluco (FBG) , um creatinino ( SCp and 24 k u- Uno putein were misuuh. Thv patUologicyt changvs of ut UP pi were odmeh undor hematoxylint eosin ( HE - staining. Resultt : Compareh with guxp A , thv patUoDgicyt changvs of Vibni / guxp B were signi/can/o
changeh. FBG and SCr and 24 k u/no putein significant-o increxh , and the diderencos were stWistWh -y significant (P <2. 26) . Compareh with guxp B , FBG , SCr and 24 k u/- nary putein / guxp C and E significant-o diuxl , and SCr and 24 k u/no putein significantly Dw-675
