工艺放大过程中需要考虑事项列表processscaleupconsiderationchecklis

更新时间:2023-07-23 16:34:57 阅读: 评论:0

Process scale up consideration check list
depositary工艺放大需要考虑的因素清单
1.purpo 目的:
气馁
This list is a compilation of the thoughts of the process engineering group. Its purpo is to share ideas from the group with all in an attempt to u the best collective thinking to improve the success of scale up of the process from lab to pilot plant. This does not consider improvements that may be made to the process by changing operations in the process.
这个清单是工艺组的思想汇总。它的目的是通过收集组内最好的思想来提高从实验室到中试车间放大的成功率。这个清单不考虑通过改变工艺的操作的提高。
x战警(第一战)电影
原版英文书jauntNo check list will allow the engineer to successfully scale up the lab process without doing the detailed considerations. 如果不做详细的考虑,没有一个检查清单可以使得工程师将实验室的工艺成功的放大。
An all inclusive checklist might have two questions: 所有包含的清单可能有两个问题:
- have all important effects been considered?所有重要影响因数是否已经被考虑到?
- will the conditions of the demonstration run be reproduced well enough in the pilot
chittagongplant for a successful run.描述的条件在中试车间中是否能够成功的生产出来?
If the answers to both of the is Yes”, the “scale usphould be successful. 如果这两个回答都是“是”,放大时成功的。
3.General effects 通常的影响:
As professional chemists and engineers doing the scale up we must make the important judgements needed to be successful. There is never enough time to gather all possible data or to simulate the PP equipment exactly in the lab. Critical judgements must be made. 作为资深的化学师和工程师在进行工艺放大时,我们必须做一些重要的判断,而这些判断为成功的工艺放大所必须的。不可能有足够的时间来收集所有可能的数据或者在实验室中来准确的评估中试设备。必须做出关键的评估。
Below is a list of parameters that may be important at any step in the operation: 以下是参数清单,这些参数在运行的每一步中都很重要。
- Time 时间
- Temperature 温度
- PH
- pressure/ vacuum压力/真空
- Materials of construction 材质
repor>宁波翻译公司- stirring 搅拌
- concentrations浓度
As you are well aware, combinations of the variables can also be important. In a heterogeneous reaction stirring may have a major effect on reaction rate. In crystallization the rate of cooling may be significant. In most reactions the profile of temperature versus time is rate of cooling may be significant. The basic variables (and their combinations) really must be considered at each; even this partial list of variables may not be too helpful in avoiding common scale up problems associated with various common actions done in the pilot plant. 如果你能很好的意识到,将几种重要的变量合并。在非均相的反应体系中,搅拌可能是最主要的影响反应收率的因素。在结晶过程中,降温速率影响会很明显。必须考虑基础的变量(和他们的综合影响)的影响。下面列表中的变量可能不是特别有帮助去解
决在中试车间放大过程中的问题。
belong是什么意思The best way to determine that the scale up operation will be successful is to u the pilot plant expected conditions in the demonstration run. This will often be significantly different from the way the PRD chemist usually makes the lab runs. 最好的方法去定义成功放大的操作是使用在中试车间放大的条件去做演示实验。这个方法明显区别于实验室化学师在实验室里做的实验。
The following is a list of important considerations for common activities in the Pilot Plant. This is a living document and should be up dated every time a new scale up effect is recognized. 下面的列表列出了在中试车间生产过程中需要考虑的一些因素,这是一个动态的文档,在放大生产过程中出现的因素都可以更新到此表中。
anglican
OSHA =occupational safety and health act [administration] 职业安全与卫生条例[管理局][美]

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