专利名称：PHARMACEUTICAL COMPOSITION
COMPRISING CYCLODEXTRIN PACLITAXEL
INCLUSION AND PREPARATION METHOD
心恋爱时代commercialinvoiceTHEREOF
背书英文发明人：Yong Ren,Jianfeng Gao,Shuqin Yu,Ling Wu
管理类 在职研究生
申请号：US12440792
申请日：20061013
公开号：US20100041625A1
公开日：
20100218
专利内容由知识产权出版社提供认为英文
北京交通大学爆炸摘要：A pharmaceutical composition comprising cyclodextrin/paclitaxel inclusion, which consists of paclitaxel, cyclodextrin and a pharmaceutically acceptable excipient, wherein the mass ratio of the paclitaxel to cyclodextrin is 1:10-150, the said cyclodextrin is hydroxylpropyl-sulfobutyl-7-β-cyclodextrin, or sulfobutylether-7-β-cyclodextrin, or their mixture; the stability constant of the cyclodextrin/paclitaxel inclusion is
Ka=5396M−1−1412M−1. The preparation method of the pharmaceutical composition is as follow: (a) A solution of cyclodextrin is added dropwi to a solution of paclitaxel in ethanol. (b) The resulting mixture is filtered through microporous membrane of 0.2-0.4μm after being dissolved. (c) Ethanol is removed under reduced pressure to give a liquid inclusion which has the ethanol level of less than 2%, or alternatively water is also removed under reduced pressure, the resulting product is dried giving a solid inclusion.
申请人：Yong Ren,Jianfeng Gao,Shuqin Yu,Ling Wu
dairy queen地址：Jiangsu CN,Jiangsu CN,Jiangsu CN,Jiangsu CN
this is怎么读erwin国籍：CN,CN,CN,CN
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