Simultaneous Effects of Multiple Factors on Solution-Mediated Pha Transformation: A Ca of
Spironolactone Forms
考研数学三教材>免费经期卫生用品
iost期刊名称： Organic Process Rearch & Development
相形见绌作者： Jia Lihong,Zhou Ling,Du Wei,Zhou Lina,Zhang Meijing,Hou Baohong,Baoconfiguration>annals
Ying,Wang Zhao,Yin Qiuxiang
年份： 2018年
韩语辅音
crunch摘要：In this work, the single-crystal structure of the ethanol solvate of spironolactone was determined for the first time. The thermodynamic stabilities of the ethanol solvate, form II, and the hydrate of spironolactone were determined from the water–ethanol–spironolactone ternary pha diagram. Meanwhile, the solution-mediated pha transformation of spironolactone forms was investigated using in situ Raman and ATR-FTIR spectroscopy. The transformation process were controlled by nucleation and growth of the stable form and/or dissolution of the metastable form in different situations.
language怎么读
cect Then the simultaneous effects of temperature and solvent composition on pha transformation were investigated in detail. The desired spironolactone form could be obtained by adjusting the temperature and the water content in the
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