英孚少儿英语加盟
台风英文
TREX1 D18N mice fail to process erythroblast DNA resulting in inflammation and dysfunctional
erythropoiesis
期刊名称： Autoimmunity
空调制冷系统作者： Stephen L. Rego,Scott Harvey,Sean R. Simpson,Wayne O. Hemphill,Fred W.actoy
Perrino
beam是什么意思>ur experience年份： 2018年
expression期号： 第7期
关键词： Exonuclea;anaemia;autoimmunity;lupus;erythropoiesis
权力的游戏第八季第五集
爱探险的朵拉第二季摘要：Anaemia is commonly obrved in chronic inflammatory conditions, including systemic lupus erythematosus (SLE), where 50% of patients display clinical signs of anaemia. Mutation at the aspartate residue 18 of the three prime repair exonuclea 1 (TREX1) gene caus a monogenic form 剖面图英文
of cutaneous lupus in humans and the genetically preci TREX1 D18N mice recapitulate a lupus-like dia. TREX1 degrades single- and double-stranded DNA (dsDNA), and the link between failed DNA degradation by nucleas, including nucleoside-diphosphate kinas (NM23H1/H2) and Deoxyribonuclea II (DNa II), and anaemia prompted our studies to investigate whether TREX1 dysfunction contributes to anaemia. Utilizing the TREX1 D18N mice we demonstrate that (1) TREX1 mutant mice develop normocytic normochromic anaemia and (2) TREX1 exonuclea participates
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