fbt专利名称：Oxime ether derivatives having lipoxygena inhibitory activity
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发明人：Dee W. Brooks,Andrew O. Stewart,Robert G.erwin
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申请号：US07/992388
申请日：19921218
公开号：US05326883A
公开日：
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19940705
专利内容由知识产权出版社提供匍匐怎么读
摘要：The prent invention provides certain substituted oxime ether compounds which inhibit lipoxygena enzyme activity and are uful in the treatment of allergic and inflammatory dia states. The compounds of this invention have the structure
##STR1## where M is hydrogen, a pharmaceutically acceptable cation, or a pharmaceutically acceptable metabolically cleavable group; p and q are independently zero or one, with the provisos that (i) p and q may not both be the same; (ii) when p is one and q is zero, R is lected from the group consisting of hydrogen, straight or branched alkyl of from one to twelve carbon atoms, and cycloalkyl of from three to eight carbon atoms; and (iii) when p is zero and q is one, R is lected from the group consisting of hydrogen, alkyl of from one to twelve carbon atoms, cycloalkyl of from three to eight carbon atoms, and --NR.sub.1 R.sub.2.
elaborateL.sub.1 is a direct bond or is lected from the group consisting of alkyl of from one to six carbon atoms, alkylenyl, of from one to six carbon atoms, and alkynyl of from two to six carbon atoms; L.sub.2 is a direct bond or is alkyl of from one to six carbon atoms; Z is lected from the group cons
isting of hydrogen, alkyl of from one to six carbon atoms,
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and halosubstituted alkyl of from one to six carbon atoms; and A is optionally substituted carbocyclic or heterocyclic aryl, arylalkyl, or aryloxy.
hayden panettiere申请人：ABBOTT LABORATORIES
代理人：Jerry F. Jansn
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